Wednesday, December 22, 2021

U.S. FDA approves emergency use of Pfizer anti-covid oral drug

Research, editing : Gan Yung Chyan, KUCINTA SETIA


News on disease control

News (1)

U.S. FDA approves emergency use of Pfizer anti-covid oral drug

Image : Reuters

The U.S. Food and Drug Administration (FDA) granted Pfizer the emergency right to use the oral Covid-19 drug "Paxlovid" on Wednesday (22 December 2021), allowing patients infected with the disease to take antiviral drugs at home before hospital admission.

This drug is recommended for people at high risk of severe covid. It is expected to be available to patients as early as this weekend.

Pfizer’s pill treatment consists of two 150-mg tablets (the new medicine) and one 100-mg HIV drug taken twice a day. This HIV drug ritonavir helps slow down the patient's metabolism, thereby keeping Paxlovid in a higher concentration in the body for a longer period of time.

The FDA approved the drug for patients 12 years and older with mild to moderate covid. The agency stated that doctors should prescribe the medication as soon as possible after diagnosis, or within five days of the onset of symptoms.

Pfizer’s CEO Albert Bourla told CNBC that the company has already shipped some pills to the United States. Once the FDA authorizes them, they can be prescribed immediately. He expects that the Centers for Disease Control and Prevention (CDC) will approve sales successfully soon.

Patrizia Cavazzoni, director of the FDA’s Center for Drug Evaluation and Research, said, “At the critical moment when new variants appear, this authorization provides a new weapon in the fight against covid, and also allows severe covid high-risk patients more likely to receive anti-epidemic treatment."

Cavazzoni said that Paxlovid will help reduce hospitalizations and deaths, and at the same time reduce the pressure on the local health care system in the spread of Omicron.

Last month, the U.S. government and Pfizer signed 10 million oral medications, with a total transaction value of 5.29 billion U.S. dollars. President Biden said that he will work hard to ensure that this treatment is available to the public for free.


News (2) to (5) / Reporter : Luo Ya / Editor/Huang Yimei / https://www.ntdtv.com/gb/2021/12/22/a103300684.html

Image : Researcher's Picture


News (2)

"Double Epidemics" severe, Xi'an locks down the city

The covid epidemic in Xi'an, Shaanxi Province is surging. In addition to the increase in confirmed cases, there has been community transmission in the area. On 22 December 2021, Xi'an announced that the entire city’s communities and units will implement closed management and control, and thousands of schools will be closed. 

Just as the covid epidemic was heating up, the local plague broke out again, and many patients with hemorrhagic fever appeared, causing panic among the people.

News (3) 

Covid status in Xi'an on 22 December 2021

Image of a royal tomb in Xi'an : Researcher's Picture

The epidemic in Shaanxi, China is surging, especially in Xi'an, and the number of confirmed cases continues to rise. As of 22 December, Xi'an has 1 high-risk area and 40 medium-risk areas.

According to Xi'an's epidemic prevention and control requirements, all seven local first-level passenger stations will be suspended from 22 December. People who leave Xi’an by car from Xi’an Railway Station or High Speed ​​Rail Xi’an North Station must hold a 48-hour nucleic acid test negative certificate, “One Code Pass”, and the green code of the itinerary code, and they must also report to their unit or street office (township). .

The authorities also used cages to surround the station to prevent people from entering.

Ms. Zhang, a citizen of Xi’an, said, "Especially high-risk control is imposed on them. They can only get in and can't get out. They have to hold 48 hours of nucleic acid and have to go to the street office to issue a certificate. If there is no certificate, they can't get out. I just saw the news. The bus line just stopped, several of them stopped. As we said above, you don’t need to go out of the city. If you don’t have to go out of the city, you are not allowed to go out of the city."

Primary and secondary schools in Xi’an began to suspend classes in the afternoon on the 20th, and many colleges and universities, colleges and universities have also begun to implement school closure measures. Residents working in Xi'an must hold a certificate of negative nucleic acid test within 48 hours. The authorities announced that the health code after the test is marked as a "red code" and needs to be quarantined.

News (4)

"One Code Communication" in Xi'an fails to work

Image of Xi'an before the epidemic : Researcher's Picture

Public places have increased the work of checking the health code. Due to the large number of people, the health code has failed many times. Even the “One Code Communication” in Xi’an has also failed. People cannot perform normal activities and the city has almost crashed.

Ms. Zhang said, "There is a problem with 'One Code Communication'. The nucleic acid I did yesterday (21st) has not come out yet. Tomorrow (23rd) I will go to the court, and the court must allow me to hold the nucleic acid for 48 hours. I can enter the court. I can’t enter the court, so I have to go, I have to tell the judge, or else he withdraws my case, what should I do?"

In the dark, there were screams from the community building. There were not enough supplies, and no one took care of sickness. The outside world did not believe it, and the people could not stand it anymore.

News (5)

Hemorrhagic fever outbreak in Xi'an worries residents

Image of apartments in Xianyang, Xi'an: Researcher's Picture

What is even more worrying is that many people have been infected with "hemorrhagic fever" in Xi'an. Since the early symptoms of hemorrhagic fever are similar to those of common flu, many patients will mistake it for a common cold.

Ms. Zhang: "Because hemorrhagic fever broke out in the Chang'an district, and its symptoms are also fever, so now officials say that the cold is cough or fever. Don't take cold medicine easily. You have to go to the hospital for examination and get rid of it. , Otherwise the hemorrhagic fever will not be cured as long as cold medicine is taken."

Mr. Chen, a family member of the Xi’an hemorrhagic fever patient: “This kind of mouse itself carries the Hantak virus, which we used to call, called the plague. Because we also feel that this disease is very far away from us, and it won’t happen to us. But since this happened, I feel that sometimes the virus seems to be by our side."

Mr. Chen, a resident of Xi’an, told reporters that his father felt like he had a bad cold from the 17th. He took a few anti-inflammatory drugs, but his condition worsened. He went to the International Medical Center Hospital for an examination and it was confirmed that it was a comprehensive renal hemorrhagic fever, but the government stipulated that This hospital prohibits treatment of this disease.

Image : Video Screenshot

Mr. Chen said, "Because the Chang'an District County Hospital, which is the First Affiliated Hospital of Jiaotong University, is a designated hospital for the treatment of this infectious disease. It is a designated hospital, and then I was taken to this hospital. After I went to this hospital, I went to I went to an outpatient clinic, went to an emergency room, and then wanted to go for treatment. As a result, because there were no beds, including this 120, they refused to treat us."

Mr. Chen said that the treatment of hemorrhagic fever is all at his own expense. More than 50,000 yuan has been spent in two days, and the financial burden is very heavy. He reminded everyone that the epidemic situation in Xi'an is so severe that one must pay attention to safety and hygiene.

Mr. Chen said, "At least 10 people in this ICU I have learned are all hemorrhagic fevers. There is a family of father and son, but his father had hemorrhagic fever before, and his son came in two days later. Both father and son came in. Going in, it is all hemorrhagic fever. The reason for our preliminary judgment is that this thing must be because my father might have been in contact with mice, or the food that the mice had torn, or the excrement of the mice was contaminated with food. The restaurant outside was not clean, and it caused this disease after eating."

The fatality rate of hemorrhagic fever is very high. Hemorrhagic fever may be infected by a mouse bitten by a mouse, eating food and water that the mouse has crawled through, or contacting the blood, urine, feces, etc. of the mouse with the virus.

News (6) to (10) / Editor : Huang Zishan / https://news.tvbs.com.tw/china/1667350

News (6)

Xi'an lockdown from 23 December 2021

Editor : Huang Zishan

Due to the covid epidemic, the city of Xi'an in Shaanxi Province, China, which has a permanent population of nearly 13 million, is locked down on 23 December 2021. The city suspends long-distance passenger transportation and implements closed management. Every family has one person to purchase daily necessities every two days. 

According to CCP media reports, Xi’an held a press conference on epidemic prevention and control in the evening of 22 December. The relevant person in charge pointed out that Xi’an plans to launch a new round of nucleic acid testing for all employees on the 23rd, suspend the city’s long-distance passenger transport, and promote citizens to stay in the city and not necessary for life. The premises are temporarily closed.

News (7)

Closed management in villages and units of Xi'an

In addition, communities (villages) and units in Xi’an  implement closed management. Every family has one person out to purchase living supplies every 2 days. Other family members work in industries that are closely related to epidemic prevention and control, urban operation guarantees, and residents’ lives. Generally, if you want to go out, you need to have a certificate issued by your unit or community. Strictly carry out the investigation and registration of foreign personnel, especially those who come and return from medium- and high-risk areas, and check the 48-hour nucleic acid test negative certificate.

News (8)

Xi'an has more new covid cases than Xianyang, Yan'an, Dongguan and Beijing

At present, Xi'an has more new cases in mainland China. Liu Feng, director of the Shaanxi Provincial Center for Disease Control and Prevention, pointed out on 21 December that in this round of the epidemic, Xi'an has seen insidious transmission, forming a certain scale of community transmission, and there have been spillover cases, spreading to Xianyang and Yan'an in Shaanxi Province, as well as Dongguan in Guangdong, Tongzhou District in Beijing and other places. According to expert research and judgment, the epidemic has entered the peak period of case reporting.

News (9)

Xi'an-related cases in Henan found

In addition, Xi'an-related cases were also found in Henan. On the 21st, 4 cases of positive persons were found in the nucleic acid test in Shenqiu County, Henan Province, and they belonged to Xi'an who returned to Shenqiu by car.

News (10)

Xi'an covid  "imported from Pakistan"

Up to now, the Shaanxi Provincial Center for Disease Control and Prevention has performed whole-genome sequencing on the specimens of 36 local cases, all of which are Delta variants, all of which are highly homologous to the imported cases found on the inbound flight from Pakistan on 4 December 2021.

News (11)

Covid status in CCP China as of 23 December 2021

As of 23 December 2021, 31 provinces (autonomous regions, municipalities) and the Xinjiang Production and Construction Corps reported 100 new confirmed covid cases. Among them, 29 were inbound cases (11 in Shanghai, 8 in Guangdong, 3 in Guangxi, 2 in Jiangsu, 1 in Tianjin, 1 in Jilin, 1 in Zhejiang, 1 in Fujian, 1 in Yunnan), including 1 asymptomatic infection. The infected were converted to confirmed cases (in Zhejiang). There are 71 local cases (63 in Xi'an, Shaanxi; 4 in Fangchenggang, Guangxi; 2 in Zhoukou, Henan; 1 case in Shaoxing, Zhejiang ; 1 case in Dongguan, Guangdong). There are 2 local asymptomatic infections (both in Zhoukou).

News (12)

Four nucleic acid-positive persons in Shenqiu, Henan were filed for investigation

In the evening of 22 December, the Shenqiu County Public Security Bureau issued a notice, deciding to file an investigation against Xie Mouhuan and other four people on suspicion of obstructing the prevention and control of infectious diseases.

News (13)

The second round of nucleic acid testing in Xi'an found 127 positive cases

From 10 am on 21 December to 12 pm on 22 December, the second round of nucleic acid screening for covi in Xi'an, Shaanxi Province, found 127 cases of nucleic acid-positive persons, who have been transferred to designated medical institutions for diagnosis and treatment.

News (14)

China's epidemic spreads to eight provinces, Delta "evolutionary branch" in Guangxi 

Reporter : Li Jinfeng / Editor : Li Quan / https://www.ntdtv.com/gb/2021/12/23/a103301130.html

The epidemic in mainland China has spread to at least 8 provinces. The latest news is that the "evolutionary branch" of the Delta virus has been found in Guangxi Province, and the two places in Dongxing City in the province have been adjusted to medium-risk areas. .

On 23 December, Guangxi city of Dongxing officially notified that starting from the 23rd, Zhouwu Group of Jianglong Village in Jiangping Town and Wanwei Village of Jiangping Town were designated as medium-risk areas.

As of 8 pm on 22 December, 4 new local confirmed cases have been reported in Dongxing City, Guangxi. From the 20th to the 22nd at 8 pm, a total of 5 local confirmed cases in Dongxing City.

Since the CCP has always concealed the truth, the outside world generally questioned the authenticity of the data.

In addition, at night of 22 December, a press conference held in Dongxing City of Fangchenggang City, Guangxi stated that the total number of nucleic acid tests for all employees in Dongxing City has reached 165,251. Nucleic acid testing in the enclosed area detected 4 people who were positive, and they were diagnosed later.

The official press conference also pointed out that after genetic sequencing, these patients were infected with the "evolutionary branch" of the Delta variant of the Chinese communis virus.

Before the outbreak in Guangxi, there were outbreaks in Shaanxi, Inner Mongolia, Heilongjiang, Beijing, Guangdong, Zhejiang, Anhui and other provinces in mainland China. The most serious one is Xi'an, Shaanxi.

On the 23rd, Xi'an added 31 medium-risk areas. Currently, there are 1 high-risk area and 71 medium-risk areas. Xi'an was closed on the 23rd, some toll stations on the expressway were closed, and the city was closed for management. Each family had one person going out to purchase daily necessities for two days.

The video taken by local citizens showed that in Chang'an University, ambulances kept coming and going. This was the same throughout the afternoon. There were so many ambulances that they did not dare to sound their horns. It was too scary.

Another online video showed that before the closure of the city, citizens rushed to buy supplies overnight. Supermarkets, vegetable markets, and farmer's markets were crowded with people, and even fighting scenes appeared.

Not only has covid severely affected Xi'an recently, but also hemorrhagic fever has occurred. The covid epidemic in Xi'an has spread to five places, namely Yan'an, Xianyang, Beijing, Dongguan, and Shenqiu, Henan. The latest news is that Xi'an epidemic-related cases have also appeared in Yuncheng, Shanxi.

On the 23rd, the Yuncheng official informed that the patient in Yuncheng was a 53-year-old truck driver who had a negative nucleic acid test in the morning of 19 December and delivered more vegetables to Zhuque Market in Chang’an District, Xi’an at 12 pm. He drove back to Shanxi at 8 pm. In the morning of the 22nd, the patient went to the County Hospital of Traditional Chinese Medicine for nucleic acid sampling, and the result was positive.

The place where the patient lived was designated as a control area in 10 venues in Jishan County and Xinjiang County. The business venues were temporarily closed, and personnel could only enter and exit.

News (15)

Singapore suspends ticket sale of VTL flights​

In order to curb the spread of the Omicron variant (Covi29), Singapore will suspend the sale of Vaccination Travel Lane air tickets and bus tickets to vaccinators from 23 December 2021 to 20 January 2022. However, all passengers who have purchased bus tickets for travel during this period will not be affected. Short-term passengers and long-term document holders can also apply for the vaccination pass.

The Singapore government will also temporarily tighten the number of tickets after 20 January and the number of passengers entering the country through VTL.

In terms of aviation, the Civil Aviation Authority of Singapore pointed out that from 21 January 2022, the number of seats on VTL flights to Singapore will be halved. According to existing arrangements, the authorities allow up to 15,000 VTL passengers to enter each day.

Singapore has so far detected at least 71 confirmed cases of Omicron covid, of which 65 are inbound, including 42 newly added on 21 December. The government therefore decided to temporarily limit the number of VTLs to reduce contact with inbound Omicron cases.

News (16)

Molnupiravir on sale in Cambodia to fight covid

Reporter : Mom Kunthear, The Phnom Penh Post


Molnupiravir, marketed in some regions as Molnatris and Monuvir, is sold at private hospitals, clinics and pharmacies of Cambodia to the public from 23 December 2021 onwards.

Healthcare businesses wishing to distribute the drug can buy it from the Ministry of Post and Telecommunications during working hours from Monday to Friday.

The announcement of its availability was made on 22 December 2021 by the working group on the management, distribution and supply of strategic drugs for the fight against covid – one of the working groups under the National Committee for Combating covid.

The notice said that in order to treat covid patients and reduce the rates of hospitalisations and mortality from the disease, the working group has imported the 200mg molnupiravir capsules with the brand name Molnatris for use in treating mild to moderate covid adult patients.

“This drug will be distributed at a price of $55 for a full treatment regimen consisting of 40 tablets. The drug will be sold from December 23 to private hospitals, clinics, pharmacies and the public under some conditions,” the notice said.

The working group set purchase limits for the 40-pill boxes – corresponding to the recommended five-day treatment course – at 10 for individuals and 200 for licensed private hospitals, clinics and pharmacies. It also capped the price at $65 per box.

The notice said buyers can re-order more after at least two weeks have passed since their last purchase through the ministry.

The Ministry of Health has advised that the drug be used only by people who are confirmed positive for covid and mainly by individuals who are at risk of developing serious illness.

The Molnupiravir 200mg pills are to be taken orally – after meals or on an empty stomach – with a glass of water and without opening up the capsule, grinding or chewing it.

“Covid patients should take 800 mg – equivalent to four tablets of 200mg each – every 12 hours for five consecutive days, or 40 tablets in total. Treatment should begin as soon as possible following a confirmed diagnosis of covid and preferably within five days of the onset of any symptoms,” the ministry said.

It noted that if patients forget to take their dose within 10 hours of the scheduled time, they should take it as soon as possible and maintain their regular dosing plan. If the patients forget to take the dose and more than 10 hours have elapsed, they should not take that dose and instead skip it and take the next dose at the correct time.

“Patients should not take twice the amount at one time to make up for forgotten doses. The safety and efficacy of molnupiravir for infants and patients under 18 years old has not yet been studied,” it said.

Citing the drug’s clinical trial data, the ministry said it can cause minor side effects such as diarrhea, nausea, vomiting, headaches and skin rash.

The drug is not recommended for women who are pregnant or intend to become pregnant because it has not been tested or approved for this group and there is a possibility of birth defects or other unknown health consequences.

Separately, health minister Mam Bun Heng issued a letter dated 22 December 2021 commending municipal and provincial governors – including health officials at all levels and volunteers – on their hard work fighting covid.

“We have to continue to work hard and encourage covi vaccinations with a standard two-dose regimen and a booster shot so that we reach our goals,” the letter read.

Bun Heng also advised them to continue to educate people to properly implement health measures and learn to adapt their lives to the new normal in the context of covid by practicing the three dos and three don’ts guideline.

Health ministry spokeswoman Or Vandine said the ministry has issued a number of advisories over the past two months reminding those eligible to receive their booster shots as soon as possible, which has now become a matter of some urgency with the emergence of the Omicron variant.

“We already have covi vaccines, but people are encouraged to get a booster shot because some people who have received the standard two-dose regimen do not seem interested in taking the third dose,” she said.

People need to get booster shots because this variant can easily infect vaccinated people, but the booster doses will help them avoid serious illness or death, she explained.

Ref: https://www.phnompenhpost.com/national/molnupiravir-sale-kingdom-aid-covid-fight


News (17)

Glutamine and glutamate : Forgotten factors in cancer

Report by: Russell Blaylock, Newsmax

Cancer cells have abnormal metabolism. Mainly, this is because they use a process called aerobic glycolysis for energy. (Normal cells use a different process called the electron transport system.)

Glucose is the main fuel for cancers, and therefore all carbohydrates feed cancers but cancer cells have other fuels. It turns out that they can use the amino acid glutamine just as efficiently as they use glucose.

In fact, some tumors are voracious glutamine consumers. Within cancer cells, glutamine is converted into another amino acid called glutamate, which is used for energy production and to stimulate receptors on the cancer cell membrane, triggering increased proliferation of cancer cells and invasion into surrounding tissues.

The list of cancers that have been shown to have glutamate receptors include:

• Colon cancer

• Breast cancer

• Prostate cancer

• Thyroid cancer

• Lymphoma

• Leukemia

• Lung cancer

• Bone cancers

• Pancreatic cancer

• Nasopharyngeal cancer

• Brain cancer

Some cancers, such as melanomas and medulloblastomas, have very high numbers of glutamate receptors. Blocking glutamate receptors has been shown to inhibit the growth and invasion of these tumors and greatly enhance the effectiveness of conventional treatments.

Most diets, even those advocated by cancer center dietitians, contain high levels of glutamate, glutamine and sugar. Unfortunately, cancer patients are rarely told that they should avoid foods naturally high in glutamate and glutamine, and processed foods containing powerful glutamate additives, such as MSG, whey protein, hydrolyzed protein, soy protein, caseinate, natural flavors, carrageenan, and autolyzed yeast.

Foods naturally high in glutamate include all meats, fish, many cheeses, green peas, all soy products, beans, tomatoes (especially pureed or as a sauce), and many salad dressings, as well as milk and milk products.

While a ketogenic diet has powerful anticancer effects, high glutamate foods should be excluded from that diet.

Inside cells, glutamine is converted into glutamate by the enzyme glutaminase. Research has shown that inhibiting this enzyme slows cancer growth.

The highest concentration of glutamine in the body is found in muscles. Terminal cancer patients lose a great deal of muscle and become emaciated (cancer cachexia) because the tumors steal the glutamine from their muscles in massive amounts.

The answer to this problem seems to be blocking the glutaminase enzyme, as that prevents the cells from manufacturing glutamate but you also have to eliminate glutamate from the diet.

Dr. Russell Blaylock, M.D., is editor of The Blaylock Wellness Report and a nationally recognized board-certified neurosurgeon, health practitioner, author, and lecturer.



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