Research, editing : Gan Yung Chyan, KUCINTA SETIA
News (2)
Zinc omnipresent in anti-coronavirus drugs
Zinc
is one of the ingredients in anti-malaria drugs.
The antimalarial drug chloroquine appears so useful in the treatment of covid because it improves zinc uptake into the cell whereas hydroxychloroquine (brand Plaquenil) uses the same pathway as chloroquine but has a safer side effect profile.
While the antimalarial drugs chloroquine and hydroxychloroquine act as a zinc ionophore (zinc transport molecule) in that they facilitate zinc absorption in the human body, other natural compounds can have the same effect.
News (3)
Zinc and zinc ionophore inhibit SARS virus,
block viral replication
Zinc
is vital for healthy immune function and in 2010, a combination of zinc
with a zinc ionophore was shown to inhibit SARS coronavirus in vitro. In cell
culture, it also blocked viral replication within minutes.
More recently, Dr. Vladimir Zelenko, who has a medical practice in New York, claims to have successfully treated 699 consecutive covid cases with a combination of oral zinc, chloroquine and the antibiotic azithromycin.
News (4)
Zinc deficiency impairs immune function
Importantly, zinc deficiency has been shown to impair immune function. As noted in a 2013 paper on zinc deficiency:
“Zinc
is a second messenger of immune cells, and intracellular free zinc in these
cells participate in signaling events. Zinc … is very effective in decreasing
the incidence of infection in the elderly. Zinc not only modulates
cell-mediated immunity but is also an antioxidant and anti-inflammatory agent.”
The problem is that zinc is largely insoluble and cannot easily enter through the fatty wall of human cells. Getting all the way into the cell is crucial as this is where the viral replication occurs. This is where zinc ionophores come in, and the fact that the antimalarial drugs mentioned act as zinc ionophores may explain why they appear so useful against COVID-19.
News (5)
Increase cellular zinc uptake with quercetin
and EGCG
A comparative study published in 2014 looked at two zinc ionophores, quercetin and epigallocatechin-gallate (EGCG found in green tea), noting many of the biological actions of these compounds may in fact be related to their ability to increase cellular zinc uptake. As explained by the authors:
“Labile
zinc, a tiny fraction of total intracellular zinc that is loosely bound to
proteins and easily interchangeable, modulates the activity of numerous
signaling and metabolic pathways. Dietary plant polyphenols such as the
flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and
as signaling molecules.
Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane.
To prove this hypothesis, herein, we have demonstrated the capacity of QCT and epigallocatechin-gallate to rapidly increase labile zinc in mouse hepatocarcinoma Hepa 1-6 cells as well as, for the first time, in liposomes … The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and thus many of their biological actions.”
News (6)
Quercetin + zinc + niacin + selenium may be a winning combo
Joseph Mercola recommends if a person wanted to try a holistic version of Zelenko’s covid protocol, the person could use a natural antibiotic such as oil of oregano, quercetin (as a zinc ionophore in lieu of chloroquine) along with oral zinc.
Chris Masterjohn recommends taking 7 mg to 15 mg of zinc four times a day, ideally on an empty stomach.
Should zinc turn out to be in short supply, consider eating more zinc-rich foods. Examples include hemp, sesame and pumpkin seeds, cacao powder, cheddar cheese, and seafood such as oysters, Alaskan crab, shrimp and mussels.
To this the consumer could also add niacin (vitamin B3) and selenium, as both play a role in the absorption and availability of zinc in the body. For example, a study published in 1991 demonstrated that when young women were on a vitamin B3-deficient diet, their serum zinc declined, suggesting B3 deficiency affected zinc metabolism such that “absorbed zinc was not available for utilization.”
A more in-depth exploration and explanation of both niacin and selenium’s relationship to zinc is provided in the 2008 paper, “Zinc, Metallothioneins and Longevity: Interrelationships With Niacin and Selenium”:
“Ageing
is an inevitable biological process with gradual and spontaneous biochemical
and physiological changes and increased susceptibility to diseases.
Some nutritional factors (zinc, niacin, selenium) may remodel these changes leading to a possible escaping of diseases, with the consequence of healthy ageing, because they are involved in improving immune functions, metabolic homeostasis and antioxidant defense.
Experiments
… show that zinc is important for immune efficiency (both innate and adaptive),
metabolic homeostasis (energy utilization and hormone turnover) and antioxidant
activity (SOD enzyme).
Niacin is a precursor of NAD+, the substrate for the activity of DNA repair enzyme PARP-1 and, consequently, may contribute to maintaining genomic stability. Selenium provokes zinc release by metallothioneins (MT), via reduction of glutathione peroxidase.
Resources
Clinical Infectious
Diseases, 2020; doi.org/10.1093/cid/ciaa237 Abstract
PLOS Pathogens November
4, 2010 DOI: 10.1371/journal.ppat.1001176
The Post Millennial
March 30, 2020
NIH Zinc Fact Sheet,
Zinc Deficiency
Advances in Nutrition
2013 Mar; 4(2): 176–190
Journal of Agricultural
Food Chemistry August 13, 2014; 62(32): 8085-8093
Journal of Enzyme
Inhibition and Medicinal Chemistry 2020; 35(1): 145–151
Science March 20, 2020;
eabb3405
Journal of Enzyme
Inhibition and Medicinal Chemistry 2020; 35(1): 145–151
Chrismasterjohnphd.com
Best Dose of Zinc for COVID-19 Prevention
World Health Net, Zinc
Rich Foods
American Journal of
Clinical Nutrition December 1991; 54(6): 1059-1064
Curr. Pharm. Des. 2008;
14(26): 2719-2732
News (7) to (12) / Reporters : Jan Jekelek and Masooma Haq, The Epoch Times PREMIUM
The public should question why governments and public health officials around the world have put little to no emphasis on outpatient treatments in their efforts to fight the covid virus, instead promoting a massive effort on vaccines, according to Dr. Peter McCullough.
“Lots of messaging on the vaccine, but zero mentioning on treatment, none. And it’s been from the very beginning. There is a theme here, I hope everyone’s starting to get the theme. There is zero effort, interest, promotion, or care about early treatment of people who are sick with COVID-19,” McCullough told The Epoch Times. “But there is a complete and total focus on people who don’t have COVID-19 and giving them a vaccine.”
McCullough is an internist, cardiologist, epidemiologist, and lead author of the first paper on early covid outpatient treatment involving a multi-drug regimen. In a recent interview with EpochTV’s “American Thought Leaders” program, he discussed a wide range of evidence on covid preventative treatments that are being used around the world.
He said drug treatments must be prioritized in the effort to stamp out the threat of COVID-19. “Early treatment markedly changes spreads. So we reduce new cases, we reduce the intensity and severity and duration of symptoms. And by that mechanism, we reduce hospitalization and death.”
News (8)
Bengal doctor uses povidone-iodine rinse to kill covi in the nose and eyes
The doctor cited recent treatments that have effectively killed the virus at the early stage of infection: Dr. Iqbal Mahmud Chowdhury conducted a protocol in Bangladesh that used a povidone-iodine rinse in the nose and eyes to kill the virus. Another treatment effort by French Dr. Didier Raoult, who treated people using hydroxychloroquine, had great success.
“Chowdhury is the first author recognizing the fact that the virus is in the air, people breathe it in, it settles in the nose, and it begins to replicate. And it has to get to a certain threshold and overcome the other organisms in the nose and overcome our own immune system to become a clinical infection. So, there’s about a three-to-five-day window to actually zap the virus directly.”
Masks and hand sanitizer are illogical and data do not show them to be effective means to prevent covi infections because the virus is spread through the air, not hands, and is too small to be blocked by most masks, McCullough said.
News (9)
Banned hydroxychloroquine useful in reducing inflammation
McCullough added covid creates “terrible inflammation” and hydroxychloroquine has been shown to be effective in reducing that, but instead of seeing an increase in using and studying the effectiveness of that drug, it has instead been restricted, and in some countries, doctors can be jailed for using it to treat their patients.
In the United States, hydroxychloroquine can only be used in hospitals.
McCullough detailed the events that led to these restrictions. “There was a falsified paper published in Lancet … which claimed to have tens of thousands of patients with COVID-19, hospitalized at multiple centers around the world, in their 40s, hospitalized with COVID-19.” He said the supposed study wasn’t verified, and it claimed the drug had negative health effects.
This “false” study led to medical professionals losing confidence in the drug, after which “hospital messaging started to say, ‘Listen, don’t use hydroxychloroquine.'”
“The NIH pulled the program on a fully funded trial in the midst of our initial wave of COVID-19. And then shortly after that, the FDA put out a statement: Hydroxychloroquine should not be used across the board, period,” he said.
“The next drug up on the block was ivermectin.”
The Epoch Times reached out to the NIH for comment on McCullough’s criticism of the NIH’s COVID-19 treatment guidelines. The NIH spokesperson declined to comment but said the NIH relied on a panel of many experts to develop the COVID-19 treatment guidelines.
The FDA told The Epoch Times that it is committed “to speed patient access to medicines to prevent or treat COVID-19 provided they meet the agency’s rigorous standards” but that the vaccines are the best way to prevent the disease and hospitalization.
McCullough said that, along with anti-hydroxychloroquine messaging, ivermectin was also maligned after the American Medical Association gave an opinion against it.
News (10)
Outpatient covid treatments including treating inflammation, blood clotting are priorities of medics, not vaccines
“So Americans saw the most confusing picture of hospitalized care of COVID-19 and a very confusing picture of outpatient treatment of COVID-19. My contributions, at least I tried to organize the outpatient treatment into concepts, where we would use drugs … in the middle phase [to] treat inflammation, and in the late phase [to] treat blood clotting, and we stuck with those principles all the way through,” McCullough said.
He said it is highly unusual for hospitals to not conduct trials on treatments for a disease, but with COVID-19, no major trials have been done to improve treatments and there have been no outcomes publicized by hospitals.
McCullough said improving treatments for those who are sick with COVID-19 has never been a priority for those in charge of public health because vaccines have been pushed from day one. He noted that CVS pharmacies were advertising the vaccines even before they were fully authorized.
CVS confirmed to The Epoch Times that it was advertising the vaccines in October 2020.
News (11)
Decontamination in the nose and mouth with "direct virucidal therapy" has stunning results
He said the U.S. media has almost completely blocked out what’s going on around the world with treatments for COVID-19. “Anywhere where there has been an early oral drug approach, there has been success in terms of COVID-19. And now more recently—it was very fascinating—is anywhere where there’s any attention to decontamination in the nose and the mouth with direct virucidal therapy, there have been stunning results.”
He questions why the United States has not reviewed the work being done around the world to treat the disease. “We haven’t seen panels of collaborating doctors. We’ve never seen a symposium on local therapy, what works best for the nose. No mention by public health officials.” McCullough says those leading U.S. public health agencies are incompetent.
News (12)
McCullough: Inpatient and outpatient therapies for covid patients should be explored
He suggests that there be a monthly review of new therapies used to treat COVID-19, both at a national and global level, for doctors to review and learn from peers. “The idea that there’s no review, you’d think the World Health Organization would actually assign a task force. This is the biggest public health problem.”
“So the treatment, inpatient and outpatient, of the biggest illness of our time, after two years, is an enigma.”
News (13)
Image : Researcher's PictureSource : The Irrawaddy
The acting president of Myanmar’s National Unity Government (NUG), Duwa Lashi La, has called the ongoing people’s defensive war against the junta, which the shadow government launched nearly four months ago, a “second struggle for independence”.
In his speech on the occasion of Myanmar’s 74th annual Independence Day commemoration on Tuesday, the acting president said that although the country is now free from colonial rule, its people continue to suffer harsh violence and repression at the hands of military dictatorships, pointing out that the military has staged coups four times over the period.
“As long as the owners of the sovereignty of the country lose their rights, we cannot say the country has achieved its independence,” he said.
Since seizing power, the junta has violently put down opposition to its coup, killing at least 1,435 people, torturing to death more than 100 detainees and arresting more than 11,300 people.
Duwa Lashi La said that in the face of the bloody attempted coup and the military’s continuing brutality against civilians, the people had no choice but to launch a defensive war to completely remove the military dictatorship.
Since the launch of the defensive war on 7 September, civilian resistance groups’ attacks on junta targets have become increasingly frequent and inflicted heavy losses on the junta’s forces. Meanwhile, the junta has also escalated its atrocities, including massacring civilians, using detained civilians as human shields, shelling and bombing residential areas, and looting and burning houses.
Fighting between the Myanmar military and the country’s ethnic armed organizations (EAOs) has also intensified, as some have joined hands with the people’s revolution.
“The most important thing at the moment is, based on the objectives of ending the military dictatorship and building a federal democratic union, all political forces including the EAOs should build unity and get involved in the people’s revolution,” the acting president said.
He dismissed coup leader and junta boss Min Aung Hlaing’s call for EAOs to mark the new year by engaging in a peace dialogue as an attempt to stall for time and find a political exit strategy from the crisis, as well as to deceive the international community and confuse the resistance forces.
“The attempted coup has trampled hopes of peace. They have destroyed the peace and future of the country,” Duwa Lashi La said.
The acting president added that in fact, the war criminals, who are stained with the people’s blood, are not fit for political dialogue, but should be sent to face domestic and international criminal courts.
The NUG has been documenting evidence of serious human rights abuses and crimes against civilians by junta forces to file with the International Criminal Court (ICC) in order to find justice for the victims.
The acting president said the revolution, for which many lives have been sacrificed in the last 11 months, will see new developments in 2022, and said he had no doubt that the people would achieve victory.
“I would like to urge [all people] to work together until we free ourselves from military slavery and bring back freedom, equality and justice for the people,” he added.
Ref: https://www.irrawaddy.com/news/burma/head-of-myanmars-shadow-govt-vows-to-continue-second-struggle-for-independence.html, https://gov.nugmyanmar.org/acting-president-duwa-lashi-la/
News (34)
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