Research, editing : Gan Yung Chyan, KUCINTA SETIA
News on disease control, CCP
Image of zinc-rich edibles : Shutterstock
News (1) to (18) / Sources : The Expose, Mercola.com / https://dailyexpose.uk/2022/04/17/zinc-helps-immune-system-regrow-immune-cells/
News (1)
March 2022 Study: Zinc helps immune system regrow immune cells
Original title: Zinc Helps Immune System Regrow Immune Cells, A New Study Reveals
Zinc has been acknowledged as an essential mineral for human health since the 1970s. More than 300 enzymes in the human body require zinc for normal function, and it is well-recognised for its role in immunity and normal immune system development.
A March 2022 study has now shed light on how zinc influences immune function. Zinc is required for the development of disease-fighting T cells, and for the regeneration of the human body's thymus, which produces T cells.
As reported by Science Daily, "In a new study published online March 25 in the journal Blood, Fred Hutchinson Cancer Research Center scientists reveal two ways the mineral supports immunity and suggest how it could be used to improve health.
"Using mice, the team discovered that zinc is needed for the development of disease-fighting immune cells called T cells and prompts regeneration of the thymus, the immune organ that produces T cells.
"This study adds to our knowledge of what zinc is actually doing in the immune system," said senior author Dr. Jarrod Dudakov, an immunologist at Fred Hutch ...
"As in humans, Iovino and Dedakov found that the thymuses of mice deprived of dietary zinc shrink and produce notably fewer mature T cells, even after as little as three weeks of a no-zinc diet, Iovino was able to show that without zinc, T cells cannot mature.
"He also found that zinc deficiency slows recovery of T-cell numbers after mice receive immune-destroying treatments akin to those given to patients about to receive a blood stem cell transplant. Conversely, extra zinc speeds this process, and T cells recover faster than normal."
A molecule inside human cells called GPR39 acts as a sensor that tracks changes in external zinc. When the level rises, GPR39 triggers the release of a key renewal factor and thymic regeneration. The researchers also found that they could trigger this regenerative process using a novel compound that mimics rising zinc levels.
Dukakov explained, "What we think is going on is, as you give zinc supplementation, that gets accumulated within the developing T cells. It gets stored and stored and stored, then he damage comes along and the zinc is released.
"Now you have more zinc than you normally would, and it can instigate this this experimental compound we can just directly target GPR39 and basically get the same effect without any of that pre-treatment."
News (2)
Zinc ionophores improve zinc's effectiveness
While zinc is a crucial mineral for normal immune function, supplemental zinc is not very bioavailable. So, to improve zinc uptake into teh cell, a zinc ionophore can be very useful.
Zinc ionophores, which act as shuttles to transport the zinc through the cellular membrane into the cells, improve zinc uptake. Getting the zinc into the cells is crucial for stopping viral replication.
Zinc ionophores include hydroxychloroquine (HCQ), chloroquine, quercetin and epigallocatechin gallate (EGCG).
The early covid treatment protocols that use HCQ is the zinc. The primary role of the HCQ is to boost zinc uptake in the cell.
Natural supplement quercetin shuttles zinc but has antiviral, anti-blood clotting, anti-inflammatory and antioxidant properties in addition to the role of zinc-shuttling. It has also been shown to inhibit blocking the ability of SARS-CoV-2 to infect human cells.
Quercetin is available over the pharmacy counter. A number of studies have shown when used early, it lowers risk of hospitalisation and death from covid and improves clinical outcomes. It has also been shown to inhibit binding of spike protein to ACE-2 receptors, thereby blocking the ability of SARS-CoV-2 to infect human cells.
News (3)
Zinc supplementation may trigger a copper imbalance
Excessive zinc supplementation can cause an imbalance in the human zinc-to-copper ratio, which can impair immune function. Copper, in turn, is interdependent on iron.
Breakdown of sources of zinc, copper and iron
Source of zinc include ready-to-eat breakfast cereals (oatmeal), poultry, baked beans, chickpeas and nuts (including cashews and almonds), kidney beans, lamb, spinach, mushrooms, pumpkin seeds, grass-fed beef, yoghurt, oysters and Alaskan king crabs.
Sources of copper include whole grains, beans, nuts, potatoes, organ meats (kidneys, livers), prunes, cocoa, black pepper and yeast.
Edibles rich in iron include poultry, seafood, beans, dark green leafy vegetables like spinach, raisins, apricots, iron-fortified cereals, bread, pastas and peas.
For all its benefits, more is not better when it comes to zinc supplementation. In fact, zinc can backfire if consumers fail to maintain a healthy zinc-to-copper ratio.
News (4)
The acceptable zinc-to-copper ratio range
As noted by Chris Masterjohn, who has a PhD in nutritional sciences, in an article and series of Twitter posts, acceptable ratios of zinc-to-copper range from 2-to-1 to 15-1 in favour of zinc. Copper appears safe to consume up to a maximum of 10 mg and "the maximum amount of zinc one could consume while staying in the acceptable range of zinc-to-copper ratios and also staying within the upper limit for copper is 150 mg/d.
Zinc intake at doses between 150 mg and 300 mg per day has been shown to decrease markers of immune function.
However, Masterjohn warns, "It's quite possible that the harmful effect of 300 mg/d zinc on the lymphocyte stimulation index is mediated mostly or completely by induction of copper deficiency."
Even intakes of 60 mg of zinc per day has been shown to lower superoxide dismutase activity, an enzyme that is important to antioxident defence and immune function and depends both on zinc and copper for normal function.
Masterjohn recommends taking 7 mg to 15 mg of zinc as supplement four times a day, ideally on an empty stomach or with a phytate-free food. He also recommends getting at least 1 mg of copper from food and supplements for every 15 mg of zinc consumed. It is best to get copper from food and not a supplement.
News (5)
Zinc-to-copper ratio imbalance can affect health
The human body zinc level is also impacted by the body copper level and an imbalance in the ratio can lead to health problems. The best way to readily achieve proper balance is to get minerals from real food grown in healthy nutrient-rich soils.
News (6)
Body signs that highlight zinc deficiency
Common signs the human body may need more zinc include lack of appetite, mental lethargy, impaired sense of taste or smell, frequent colds, flu or infections, hair loss and poor neurological function.
Individuals at higher risk for zinc deficiency include those with malnutrition, persistent diarrhoea, the elderly, people with inflammatory or autoimmune diseases, chronic alcoholics, vegetarians and vegans.
News (7)
Zinc deficiency is a global threat
Experts believe that about 17.3% of the global population are deficient in zinc. It is estimated most people over 65 years old consume just 50% of the recommended amount.
The shortage may be in part due to the result of soil depletion of zinc because of conventional farming methods and may also simply be that not enough zinc-rich edibles are included in the diet. Severe deficiency, however, is rare, and often associated with an inherited condition called acrodermatitis enteropathica.
News (8)
Zinc is as precious as water
Zinc is the second most abundant trace mineral found in the human body but our human body cannot store it very well. So we should consume edibles with zinc daily to meet our bodies' needs.
News (9)
300 enzymes in the human body require zinc to function
More than 300 enzymes in the human body require zinc for normal function and it is will-recognized for its role in immunity and normal immune system development.
Research in the last decade has identified the crucial role that zinc plays in curtailing the length and severity of upper respiratory infections in particular. For example, a meta-analysis published in 2017 found those who took a zinc supplement of 80 to 92 mg each day at the beginning of cold symptoms saw a reduction in the length of their cold by 33%.
News (10)
Zinc deficiency can increase risk of severe covid
Research published in 2020 also demonstrated that zinc is crucial to immune system function. Deficiency of zinc can raise a person's risk of severe covid. Early on in the pandemic, a number of doctors who were treating covid patients recognise the importance of zinc and published early treatment guidelines that included it.
News (11)
How zinc influences immune function
Zinc affects the human body immune function and helps prevent infections in a variety of ways. For example, data have shown that people who are deficient in zinc have an increased susceptibility ti pathogens as zinc helps prevent viruses from entering and replicating inside human cells.
Zinc mediates non-specific immunity including natural killer cells and neutrophils.
Zinc deficiency prevents the activation of T-lymphocytes, production of Th1 cytokine and the ability of B lymphocytes to help. During deficiency, B lymphocyte development is also compromised.
Deficiency affects the function of macrophage cells, which can trigger cytokine production and dysregulated intracellular death. Thus, with a deficiency in zinc, a person not only get more viral infections but these trigger an increase in hyperinflammatory response.
News (12)
Copper found in vitamin C enzyme
Whole food vitamin C can also be helpful as vitamin C contains an enzyme called tyrosinase, which has two copper atoms in it. The cherry endemic to Brazil, acerola, is one excellent source of tyrosinase. The consumer may want plenty of saturated fats in the diet as copper is a fat-soluble mineral. If there is no fat in the diet, the ability to absorb copper plummets.
News (13)
Copper highly interdependent on iron
Copper is highly interdependent on iron and needs to be considered together when consuming zinc. If there is not enough copper in the diet, haemoglobin production becomes impaired, along with many other aspects of iron metabolism. So, being anaemic does not automatically mean that one is iron deficient. One may be deficient in copper. Anaemia typically relates to iron dysfunction or dysregulation, not deficiency.
News (14)
Anaemia is not the result of iron deficiency
The common misconception that anaemia is always the result of insufficient iron is tragic as excess iron increases oxidative stress and causes metabolic dysfunction. Mitochondria are crucial energy recycling centres. Iron needs to be recycled through the mitochondria into either haem or iron-sulphur clusters and both also require copper in the conversion.
Anaemia, characterised a low serum iron and low serum ferritin, is not a sign of insufficient iron but rather a sign that the iron is not being properly recycled due to insufficient copper.
News (15)
The acceptable iron-to-copper ratio
The ideal ratio of iron-to-copper is on average 50-to-1. Ideally, the consumer would have about 5,000 mg of iron and about 100 mg of copper.
News (16)
Most people have elevated iron, donate blood if there is excess
Most men and postmenopausal women have excessive iron and can benefit from regular blood donation. Accummulate about 1 mg of iron daily, based on the research of leading Iron biologists. Unless blood is lost, retain that amount. By 65 years old, 20,000 mg of storage iron may have been accumulated.
Storage iron will radically increase the oxidative stress and tissue damage in the human body. It is also one of the most common causes of fatigue because of how it impairs the mitochondrial production of energy.
When donating a pint or half-litre of blood, remove approximately 250 mg of iron from body's tissue iron. Donating four pints a year is far more than most people do but if one had 20,000 mg of storage iron, it would take 20 years of blood donation four times a year to get it down to a healthy level.
News (17)
Do not lose 10% of blood in one sitting
While regular blood donation is a highly effective way to lower iron, losing 10% of blood in one sitting can be a problem for many. So remove blood in smaller amounts monthly; men are recommended to remove 150 ml of blood, postmenopausal women 100 ml and premenopausal women 50 ml.
News (18)
Consult doctor before blood donation
Avoid blood donation if there is congestive heart failure and discuss with doctors if necessary before going ahead to donate blood.
News (19)
3 new deaths in Shanghai, the direct causes of deaths are the underlying diseases
Reporter : Chen Jing / https://www.chinanews.com.cn/sh/2022/04-18/9732069.shtml
At the press conference on the prevention and control of the covid epidemic in Shanghai held on 18 April 2022, Wu Ganyu, a first-level inspector of the Shanghai Municipal Health Commission, said that on 17 April Shanghai added a new 2,417 local confirmed cases of covid and 19,831 local asymptomatic infections, with 3 new deaths.
The dead cases are all elderly people, two women and one man, aged 89 and 91, respectively. They had severe underlying diseases such as acute coronary syndrome, diabetes, hypertension, and cerebral infarction sequelae, and none of them had been vaccinated against covi. After they were admitted to the hospital, their condition worsened, and the rescue failed and they died. The direct causes of deaths were caused by the underlying disease.
Wu Qianyu introduced that at present, there are 16 severe patients receiving treatment in designated medical institutions.
News (20)
People's grievances are boiling and want to solve the problem? It is rumoured that Shanghai forced to "achieve social zero-covid" by 20 April 2022
Reporter : Zheng Gusheng / Editor: Lin Qing / https://www.ntdtv.com/gb/2022/04/17/a103402814.html / Image : It is said that Shanghai officials have set a goal of "not spreading the virus outside the quarantine area" by 20 April 2022. The picture shows a covid nucleic acid test in a community in Pudong, Shanghai, on 17 April. (Liu Jin/AFP via Getty Images)
The CCP's brutal blockade and control of Shanghai created a humanitarian disaster. According to Reuters news, the authorities issued a death order requiring "no transmission outside the quarantine area" on 20 April 2022, which is suspected to be eager to solve the problem.
Reuters reported on 17 April, citing two people familiar with the matter, that Shanghai officials have set a goal of "not spreading the virus outside the quarantine area" by 20 April, and have communicated it to officials at all levels and schools and other organizations.
According to the report, Chen Jie, secretary of the Baoshan District Committee of the Communist Party of China, said in an internal speech on the 16th that the working group of the State Council of the Communist Party of China, the Shanghai Municipal Party Committee and the municipal government requested that the Shanghai epidemic should reach an inflection point on 17 April, and should be “cleared" to "achieve social zero-covid" on the 20th.
Chen Jie said the order comes at a time when the situation in the city has reached a "critical moment", with public anxiety and increased pressure on food supplies.
Chen Jie emphasized that "this is a military order, and there is no room for bargaining." Officials at all levels must go all out to fight the "last battle to reverse the trend of the epidemic."
According to CCP official media reports, Sun Chunlan, Vice Premier of the State Council of the Communist Party of China, and Li Qiang, Secretary of the Shanghai Municipal Party Committee, who were “supervising the war” in Shanghai, continued to emphasize that they “adhere to the zero-covid policy and never waver” and Sun Chunlan has begun to publicize that "zero-covid is just around the corner".
The Central News Agency reported that "clearing" is a necessary condition for unblocking. The CCP authorities ordered "social zero-covid" on 20 April, showing that they are eager to get out of the epidemic prevention quagmire in Shanghai. However, whether Shanghai, where at least hundreds of thousands of people have been infected, can really achieve "social zero" within 3 days from the 17th, still makes the outside world and even the locals in Shanghai doubt.
The so-called "social zero-covid" means that there are no infected covid cases outside the blockade and isolation areas. This concept was pioneered by the Xi'an authorities. At that time, it was questioned by public opinion and they were deceived. The so-called anti-epidemic measures of the CCP often do not take into account the real situation but are just out of political needs, and they continue to falsify in order to achieve political goals.
A few days ago, screenshots of chats in the internal group of Shanghai First People's Hospital were posted online, and it was suspected that the authorities had begun to cover up the epidemic and used "technical means" to "clear the infection figures." Local netizens who broke the news said that this means that the authorities have admitted in disguise that they have "failed to clear the system off covid."
Image : A screenshot of the chat in the internal group of Shanghai First People's Hospital.
Various sources of information show that the Shanghai authorities are accelerating the "social zero-covid", including speeding up the discharge of patients at isolation points and expanding the scope of requisitioned isolation points to alleviate the serious shortage of isolation cabins. People in many places protested the establishment of quarantine points in the community. Residents of the Nashi International Community in Zhangjiang Town were also forced to be used as isolation points for resisting residential buildings, and were violently suppressed by the public security.
Another news shows that more than 8,700 people in Lianqin Village, Cai Town, northeast Shanghai Pudong District, were transferred and quarantined on the 16th due to the increasing number of positive cases.
According to official reports, the Shanghai Municipal Commission of Economy and Information Technology announced on the 16th the "Guidelines for the Resumption of Epidemic Prevention and Control of Industrial Enterprises". The Shanghai factories of FAW and Tesla, which belong to the leading Chinese and foreign auto companies, as well as some semiconductor factories, are the first to plan to resume work in batches from 18 April. These measures are also seen as echoing the official will to call for a "turn in the epidemic."
The Central News Agency commented that only when a "social zero-covid" is achieved, can the authorities further consider a certain degree of "unblocking" to alleviate the strong public grievances that are on the verge of erupting in Shanghai. Otherwise, the so-called "social stability" and even "political security" demanded by the CCP, especially the 20th National Congress of the Communist Party of China in the second half of the year, will be impacted by this public grievance.
Therefore, it is the top priority for the Beijing and Shanghai authorities to withdraw from the quagmire as soon as possible to suppress the high-fever epidemic. As for how to deal with the infected people who have slipped through the net afterwards, and how to deal with the huge number of infected people who are quarantined, it is after withdrawing from the quagmire. Then try to wash the "little things".
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