Thursday, October 6, 2022

Responsibly disengage from Myanmar Junta and Junta's nuclear plans exposed

 Research, editing : Gan Yung Chyan, KUCINTA SETIA

News on Myanmar, disease control, CCP, Taiwan

News (1) to (12) / Sources : Myanmar Now, The Irrawaddy

News (1)

Activists call on Singaporean oil company to "responsibily disengage" from Myanmar
Image : A Puma Energy oil tanker is seen at the company’s petroleum products terminal at Thilawa Port in Yangon in 2017 (EPA)


Rights groups have called on Singapore-based oil company Puma Energy to commit to “responsible disengagement” after it announced its exit from Myanmar on 6 October 2022.

 

Puma Energy said in a statement that it had decided to sell its stake in the joint venture Puma Energy Asia Sun (PEAS) and its minority share in the National Energy Puma Aviation Services (NEPAS) to a locally owned private company. NEPAS is operated in partnership with the junta-controlled Myanmar Petroleum Products Enterprise. 

 

Through these ventures, Puma Energy has been Myanmar’s main supplier of aviation fuel since it commenced operations in 2015 and launched a multimillion dollar petroleum product terminal at Thilawa Port in Yangon two years later. 

 

Montse Ferrer, Amnesty International’s Business and Human Rights Researcher, said that the company’s decision to withdraw from Myanmar follows a long campaign by civil society and rights groups to ban jet fuel from reaching the Junta. The fuel supply is critical to the military’s continued perpetration of airstrikes widely used against civilian populations nationwide, and responsible for displacing tens of thousands of people.

 

Ferrer urged Puma Energy to ensure that the military is prevented from accessing its aviation fuel infrastructure once the company has withdrawn from the country. “Any valuable assets Puma Energy leaves behind should not fall into the hands of the military or its crony businesses,” he said in a statement. 

 

Since the February 2021 coup, the Myanmar Junta military has relied heavily on air power to attack armed forces opposed to its rule, killing many civilians and members of the resistance groups.

 

Ferrer encouraged Puma Energy to identify ways it could “remedy any harm” it may have caused while operating in Myanmar.

 

Another rights group, Justice For Myanmar, stressed that Puma Energy had not announced the name of the local company to whom it is selling its shares in PEAS and NEPAS and asked that it urgently disclose further details on the matter. 

 

Justice for Myanmar called on the company to engage with civil society groups and the publicly mandated National Unity Government regarding the exit process. The group also urged foreign governments to take immediate action to stop the Junta’s “indiscriminate air strikes” by imposing a ban on jet fuel to Myanmar.

 

Puma Energy is 49 percent-owned by Geneva-based global commodities trader Trafigura. Shortly after the February 2021 coup, Puma Energy said it was suspending its activities in Myanmar. It subsequently resumed operations reportedly for civilian purposes, according to Amnesty International’s statement, which cited information provided by the company.


News (2)


Myanmar's main supplier of aviation fuel withdraws from country


Puma Energy, the midstream and retail arm of Switzerland’s Trafigura and the main supplier of aviation fuel in Myanmar, announced on Wednesday that it has sold its operations in the country to a locally owned company, becoming the latest multinational to withdraw from military-ruled Myanmar.

The company has signed an agreement to sell its stake in Puma Energy Asia Sun (PEAS) and its minority share in National Energy Puma Aviation Services (NEPAS) to a locally owned private company, the statement said, without naming the buyer.

NEPAS is a joint venture between Puma Energy and the state-owned Myanmar Petrochemical Enterprise under the junta’s Ministry of Energy, and engages in import and distribution of aviation fuel.

Puma initially suspended its operations in Myanmar following the military coup in February 2021 but later resumed distribution for civilian purposes.

In August, Myanmar Junta reconstituted a state-level coordination committee on aviation fuel with the stated purpose of importing, storing and distributing aviation fuel in line with international norms.

The 15-member committee consists of directors-general from the Energy, Transport and Communications, Planning and Finances, the assistant quarter-master general, and chiefs of the state flag carrier Myanmar National Airlines and private airlines including Air Thanlwin, Myanmar Airways International and Golden Myanmar Airlines.

News (3)

War against Myanmar Junta: At least 15 Junta personnel killed in 2 days

At least 15 junta forces including a pro-junta militia leader were reportedly killed during attacks by People’s Defense Force (PDF) groups and ethnic armed organizations (EAOs) targeting regime forces in the last two days.

Myanmar has seen clashes and urban attacks involving PDFs and EAOs in Yangon, Sagaing, Bago, Ayeyarwady and Tanintharyi regions and Karen and Rakhine states.

News (4)

Ward administration office bombed in Yangon

The Yangon Underground Association (YUA) claimed that member organization Generation Z Defense Force (GZDF) managed to bomb the junta-run Kyaungkone Ward administration office in Shwepyithar Township, Yangon on Wednesday afternoon.

The group used two remote-controlled bombs to attack the office. In the attack, an office staffer and some civilians who were visiting the office to register on guest lists were injured.

The group apologized for injuring civilians and urged people to avoid regime forces, their allies and junta-run offices and departments due to potential attacks.

News (5)

Junta official’s store bombed in Yangon

Yangon-based resistance group the South Dagon Guerrilla Force (SDGF) claimed to have bombed the liquor store of junta-appointed ward administration member U Aung Kyaw Saw in the Yusana Garden Housing complex in South Dagon Township, Yangon on Wednesday night.

The group said the attack was intended as a warning to the owner to stop contributing to the junta and selling the military-linked product Myanmar Beer. A vehicle was also damaged in the attack.

News (6)

10 Junta soldiers killed in upper Sagaing

At least 10 junta forces including an army officer were reportedly killed in Kyunhla Township, Sagaing Region on Tuesday when the township PDF group and PDF Battalion 1 of Kantbalu District attacked a military detachment of 40 troops traveling to a village near Tha Phan Seik dam, local media outlet Infinity Group reported.

Many troops were injured in the clash. There were no PDF casualties, Infinity said.

News (7)

Junta-run immigration department bombed in Sagaing

Two junta soldiers were seriously injured in the town of Sagaing, Sagaing Region on Tuesday when the People’s Dictatorship Revolutionary Force-PDRF bombed the immigration office, the group said on Wednesday. Some office staff were also injured.

The group urged civilians to avoid regime forces and junta-run departments due to potential attacks.

News (8)

Four Junta forces killed, injured in Bago

A junta police officer was killed and three others including a Pyu Saw Htee pro-regime militia member were injured during a firefight with the Bago Region PDF group in Paukkhaung Township, Bago Region on Wednesday, according to the resistance group.

A shootout broke out between two villages when the PDF fighters ambushed regime forces escorting a group of junta-appointed administrators returning from a meeting. 

News (9)

Pro-junta militia leader killed in Ayeyarwady  

Ayeyarwady Dolphin PDF group claimed to have killed U Khin Maung Kyi, the leader of a pro-junta Pyu Saw Htee militia, in Mawlamyaingkyun Township, Ayeyarwady Region on Wednesday evening.

The assassination was part of Operation Nann Htike Aung, the group said, adding that it will continue to target junta informants, administrators and businesses contributing to the military regime. People are urged to avoid them, it said.

News (10)

Pro-junta militia member arrested in Tanintharyi

Pyu Saw Htee pro-regime militia member Ko Naing, 35, was arrested and his M-16 rifle and ammunition seized by the PDF group Dragon Soldiers of Tanintharyi on Tuesday evening while he was going out to bathe near Nyaung Pin Kwin Village in Tanintharyi Township, Tanintharyi Region, the PDF group said on Wednesday.

News (11)

KNLA, resistance snipers kill three junta soldiers in Karen

Three junta soldiers were killed in Myawaddy Township, Karen State on Wednesday when resistance snipers of the Karen National Liberation Army (KNLA) and allied resistance groups ambushed regime forces of Light Infantry Battalion 104 attempting to occupy an area near Taung Ni Village, said KNLA’s cobra column.

Clashes have been reported nearly every day for weeks, as Junta forces have been trying to conduct raids in the area.

On Wednesday afternoon, a fierce clash broke out in the township when KNLA and Cobra Column troops attacked regime forces of three military battalions attempting to occupy the Lukhoe area with 120-mm artillery support from two junta outposts nearby.

Resistance forces also responded to the junta raid with drone strikes. In the clash, at least three soldiers were injured, but no casualties were reported on the resistance side.

News (12)

Clash breaks out in Rakhine

A clash erupted between junta forces and the ethnic Arakan Army (AA) near Thayatpyin Village in Buthidaung Township on Wednesday morning, according to local media.

Details of casualties were not known for either side.

The same morning, villages near Manyin Mountain were attacked by a junta jet fighter and military forces stationed on the mountaintop using heavy explosives, despite the fact that no clash was occurring with AA troops.

On Wednesday night, junta forces randomly fired artillery shells at villages in Minbya and Buthidaung townships without provocation. Due to the junta shelling, a 40-year-old female internally displaced person from Pharpyo Village was injured while sheltering in Kyantike Village in Minbya.

News (13)

Myanmar Junta's nuclear ambition timeline exposed

The junta’s recent confirmation that it will build a small-scale nuclear power plant in the next few years caps Myanmar’s long pursuit of nuclear technology dating back to early 2000.

The Southeast Asian country’s two-decade-long journey to nuclear capability was made possible by Russia after a series of engagements that accelerated under the current junta and its military predecessor.

Though the current regime insists nuclear energy would be used for peaceful purposes in Myanmar, which has been hit by chronic electricity shortages, many believe this is the first step in a plan to utilize nuclear energy for military purposes including production of nuclear weapons.

The timeline on Myanmar’s long road to nuclear technology:

January 2002

The Myanmar military regime confirms plans to build a nuclear research reactor “for peaceful purposes.”

May 2002

Russia’s Atomic Energy Ministry, Minatom, agrees to help Myanmar build a nuclear studies center comprising a 10-megawatt nuclear reactor and two laboratories, in Magwe Division, central Myanmar. The agreement includes the construction of facilities for disposing of nuclear waste and Russian training for Myanmar technicians.

July 2002

Russia and Myanmar sign an agreement in Moscow on construction of the proposed nuclear research center in Myanmar.

9 April 2004

Keith Luse, an aide to US Senator Richard Lugar, asks whether North Korea is providing nuclear technology to Burma, during a Washington seminar organized by the Heritage Foundation, a conservative think-tank.

13 February 2004

The military regime declares that it has “no desire” to develop nuclear weapons, but “has the right to develop nuclear facilities for peaceful purposes.”

14 September 2004

About 400 young military officers from Myanmar leave for Russia amid reports that some of them will study nuclear engineering.

3 August 2006

Myanmar’s deputy ambassador to the UN Nyunt Swe tells the UN Conference on Disarmament in Geneva that Burma is opposed to nuclear weapons.

15 May 2007

Russia’s federal atomic energy agency Rosatom announces it will help Myanmar build the proposed nuclear facility. The agency says the 10-megawatt nuclear reactor, fueled by less than 20 percent uranium-235, will contribute to Myanmar’s “research in nuclear physics, biotechnology, material science as well as…produce a large variety of medicines.” The first round of talks o­n project details begin.

16 May 2007

The US condemns the project, while Thailand says it has no worries because the facility will be closely supervised by the International Atomic Energy Agency.

November 2008

A 17-member high-level Myanmar military delegation led by then junta No 3 Thura Shwe Mann makes a secret seven-day visit to Pyongyang via Beijing, during which the two sides sign agreements to deepen military cooperation.

Shwe Mann and his delegation also visit Myohyang in North Korea, where secret tunnels have been built into the mountains to store and shield jet aircraft, missiles, tanks, missiles, and nuclear and chemical weapons. The visit arouses concerns about the Myanmar military’s nuclear ambitions.

In 2012, while serving as Speaker of the Lower House under U Thein Sein’s quasi-civilian government, Shwe Mann claims the delegation to North Korea observed the air defense system and signed a memorandum of understanding for cooperation between two armies, while nuclear weapons were not on the agenda.

2010

Major Sai Thein Win, an engineer in the Myanmar military’s Science and Technology Workshop (known locally as the “nuclear unit”) with a doctorate in atomic energy from Russia, publicly reveals information, including photos, showing that the military regime is studying the possession of nuclear weapons with technological help from North Korea.

July 2013

Lt-Gen Thein Htay, who heads the Directorate of Defense Industries is placed on a US Treasury sanctions list for illicit trade in North Korean arms to Myanmar. He was part of Shwe Mann’s delegation to North Korea in 2008. Today, he serves as a weapon production advisor for the current regime.

2016

Myanmar signs the Comprehensive Nuclear Test Ban Treaty under the democratically elected government led by Aung San Suu Kyi’s National League for Democracy. Aung San Suu Kyi hands over the ratification instrument to United Nations Under-Secretary-General Miguel de Serpa Soares.

2018

Myanmar’s bicameral parliament approves President U Win Myint’s proposal for Myanmar to ratify the Treaty on the Prohibition of Nuclear Weapons. Union Minister for International Cooperation U Kyaw Tin signs the treaty during the UN General Assembly in September.

September 2022

The Myanmar Junta and Russia’s state-owned nuclear corporation Rosatom sign a roadmap for further atomic energy cooperation, including possible implementation of a modular reactor project in Myanmar.

The agreement is signed on the sidelines of the Eastern Economic Forum (EEF-2022) in Vladivostok, Russia, which is attended by regime chief Min Aung Hlaing.

20 September 2022

Junta spokesman Maj-Gen Zaw Min Tun briefs press, confirming the regime’s plan to implement a small nuclear power plant project in the next few years.

He does not specify the project’s location but says the Atomic Energy Department of the Junta’s Ministry of Science and Technology will establish a “nuclear information technology center” in Yangon, which will gauge and influence public opinion on nuclear energy.

Refs: https://www.irrawaddy.com/news/burma/myanmar-juntas-nuclear-ambition-timeline.htmlhttps://www.irrawaddy.com/news/burma/myanmars-main-supplier-of-aviation-fuel-withdraws-from-country.htmlhttps://www.myanmar-now.org/en/news/activists-call-on-international-oil-company-to-responsibly-disengage-from-myanmarhttps://www.irrawaddy.com/news/burma/myanmar-resistance-ethnic-forces-kill-at-least-15-junta-personnel-in-two-days.html

News (14) to (16) / Reporter : Luo Tingting / Editor : Wen Hui / https://www.ntdtv.com/gb/2022/10/06/a103545023.html

News (14)

On the eve of the 20th National Congress, Shanghai strengthens nucleic acid testing, Haikou locked down
Image : On 20 September 2022, a Shanghai man was undergoing a nucleic acid test. (Hector Retamal/AFP via Getty Images)
The 20th National Congress of the Communist Party of China is approaching, outbreaks have broken out in many tourist areas in China, Shanghai has strengthened nucleic acid testing, and Xuhui District has announced 4 inspections in 5 days. Haikou City, Hainan announced the closure of the city on the 6th, and the city implemented static management.
News (15)
Nucleic acid testing strengthened in multiple districts in Shanghai
The Shanghai Municipal Health Commission reported on 5 October that 6 new cases of local asymptomatic infections were added on the 4th, distributed in Hongkou District, Jiading District, Songjiang District, Qingpu District and Fengxian District. Several administrative districts have successively announced to strengthen nucleic acid testing.
Xuhui District announced that from 5 to 9 October, the whole district will carry out 4 nucleic acid tests for all employees. The community is closed and managed, and residents can prove the community with 24-hour nucleic acid sampling. Employees of businesses, enterprises and institutions can enter and leave the workplace with a 24-hour nucleic acid sampling certificate.
Huangpu District and Yangpu District also announced that they will conduct nucleic acid screening for all employees in the entire district on 5 and 7 October. During the period, communities, parks, buildings, shops along the street, and hotels will be closed and managed, and will be lifted after the sampling.
Xinghuo and Liaoyuan in Haiwan Town, Fengxian District have launched 4 inspections in 4 days on the 4th. In addition, other administrative districts in Shanghai have also announced to strengthen nucleic acid testing.
News (16)
Zhangjiajie emergency search, Hohhot public transport suspend operations
Hainan Haikou announced on t6 October that the city will implement static management. Guanghan City, Sichuan Province requires the entire city to conduct nucleic acid testing for all employees, and all residents are in principle at home.
Zhangjiajie, Hunan Province notified on 5 October that there are many high-risk personnel in Yongding District's 72nd Qilou, and they are urgently searching for relevant personnel and conducting "2 inspections in 3 days". The notice also requires all personnel in Zhangjiajie to "do not leave the province unless it is necessary" and "do not leave the city unless it is necessary."
On 6 October, temporary static management was implemented in the streets of Yongding District of Zhangjiajie and the whole area of ​​Wulingyuan District.
Fenghuang County, Hunan Province discovered the epidemic on 6 October, and implemented a global silent control, and residents did not go out unless necessary.
On the 5th, 4 cases of abnormal nucleic acid test results were found in Tongcheng, Anhui. From 8 am on the 6th, the main urban area, the whole area of ​​Fangang Town, and the whole area of ​​Qingcao Town were controlled.
Hohhot, Inner Mongolia, reported 19 new confirmed cases and 441 asymptomatic infections on the 5th. All buses in the city were suspended until further notice.
The 20th National Congress of the Communist Party of China will be held in 10 days, and the epidemic prevention and control in many places in China has increased. Inner Mongolia claimed to "kill chickens with a bull's knife" in dealing with the epidemic; Xinjiang suspends passenger trains leaving Xinjiang and "do not leave Xinjiang unless necessary".
Xishuangbanna, Yunnan Province is under lockdown throughout the state. Tourists and citizens will not leave the state unless it is necessary. Those who leave the state are required to undergo 5-day health monitoring. Videos leaked online showed that thousands of tourists were trapped at Xishuangbanna Airport. Police officers armed with firearms and shields suppressed tourist protests in the airport lobby. Many were violently arrested.
Beijing stipulates that it is strictly forbidden for people from counties, cities and towns who have an epidemic within 7 days to enter and return to Beijing.
Shanghai, Tianjin, Zhejiang Hangzhou, Guangdong Guangzhou, Hunan Changsha, Henan Zhengzhou, Shandong Jinan, Shanxi Taiyuan, Fujian Fuzhou, Liaoning Shenyang, Shaanxi Xi'an, Gansu Lanzhou, Qinghai Xining and other places all stipulate that those who have a history of living in high-risk areas within 7 days after returning,will be quarantined for 7 days; those with a history of living in medium-risk areas within 7 days will be quarantined at home for 7 days.
Lhasa, Tibet stipulates that those who have a history of living in high and medium risk areas will in principle be suspended from entering (returning) Tibet. 7-day centralized quarantine is required for those with a history of travel and residence in high-risk areas; 7-day home quarantine is required for those with a history of travel and residence in medium-risk areas.
Mainland netizens complained, ​“The holidays caused by the epidemic are very messy, and it is not safe to go anywhere. Who knows when it will become a close connection or time-space companion by accident. It may delay going to work or school, and staying in hotels at your own expense is enough to be irritated. ."
News (17)
After the 20th National Congress of the Communist Party of China, the policy of "dynamic clearing" will remain unchanged? Public anger will be ignited again! 
Reporter/Editing : Qin Rui / https://www.aboluowang.com/2022/1006/1812400.html / Image : Web Screenshot
Recently, the Internet media "Hong Kong 01" of the CCP Jiang Zemin and Zeng Qinghong factions published a series of reports related to the 20th National Congress of the Communist Party of China, one of which is the "Top 20 Task List".
On 26 September 2022, this series published an article titled "Starting from the isolation of the country, seeking stability is still a consensus", which pointed out that in September before the 20th National Congress of the Communist Party of China, an epidemic broke out in China again. This time, it affected nearly 100 cities in more than 20 provinces, municipalities and autonomous regions. According to media statistics, at the beginning of September, 33 cities, including 7 provincial capitals and 1 municipality directly under the Central Government, implemented partial or global travel restrictions. From Wuhan in 2020 to the current N wave of the epidemic, nearly 300 cities in China have been closed to varying degrees.
Huang Yanzhong, a senior researcher on global health issues at the Council on Foreign Relations of the New York think tank, wrote in a book on 8 April 2022 why Xi Jinping could not withdraw from the zero-covid policy, because the costs and benefits of the zero-clearing policy were highly politicized, and abandoning the policy would It means losing the ruling legitimacy of the CCP and the personal leadership of Xi Jinping.
Therefore, the "dynamic clearing policy" has naturally become an important target for the Jiang Zeng faction to attack Xi Jinping, because criticizing the "clearing policy" will allow the Jiang Zeng faction to easily occupy the high ground of morality and public opinion.
The article "Hong Kong 01" pointed out that the outside world is very concerned about whether the 20th National Congress of the Communist Party of China will change the "dynamic clearing" policy. The outside world "hopes that China's epidemic prevention policy will be loosened after the 20th National Congress of the Communist Party of China, which is regarded as the most urgent task list."
However, the article said, "combining various sources and the official continuous release" adherence to the general policy of 'dynamic clearing' is a summary of my country's successful experience in dealing with the new crown pneumonia epidemic. important achievements”, the press conference of the joint prevention and control mechanism of the State Council of China also constantly emphasized that “we must unswervingly adhere to the general strategy of 'foreign defense import, internal defense rebound' and the general policy of 'dynamic clearing'", so it is generally judged that "dynamic clearing" The "zero" policy will not change, but there will be higher requirements for "scientific and precise control of the epidemic,..."
Since September, online rumors that "dynamic clearing will become a basic national policy" have successfully ignited public anger.
Some self-media articles mentioned: "At the State Council press conference on 7 September, Chang Jile, deputy director of the National Bureau of Disease Control and Prevention, also made it clear that dynamic clearing will be a basic national policy for a long time."
Since then, despite the so-called refutation of rumors by the media, such news immediately aroused public anger in mainland China, which has been under strict epidemic control for nearly three years.
Some netizens questioned that even though the CCP official did not explicitly say that dynamic clearing is a national policy, various strict epidemic prevention and control policies have proved that dynamic clearing is a "national policy".
The few dozen words of the Jiang Zeng faction are undoubtedly an incendiary bomb dropped before the 20th National Congress, which will reignite public anger.
News (18) to (20) / Reports by : Galileo, The Paper / https://news.sciencenet.cn/htmlnews/2022/10/487296.shtm
News (18)
Famous virologist Wu Jianguo died of a sudden illness in Foshan at the age of 66
Wu Jianguo, a famous virologist, former director of the State Key Laboratory of Virology, professor of the School of Life Sciences of Wuhan University, and director of the Institute of Pathogenic Microbiology of Jinan University, died on 3 October 2022 at 1.07 am due to a sudden illness. He passed away at the age of 66 in Foshan, Guangdong.
In the afternoon of October 4, the WeChat public accounts of the State Key Laboratory of Virology of Wuhan University and the Foshan Institute of Pathogenic Microbiology successively issued obituaries.
Dr. Wu Jianguo is also a Distinguished Professor of the "Changjiang Scholar" of the Ministry of Education, an expert enjoying special government allowances from the State Council, the director of the Institute of Pathogenic Microbiology of Jinan University, the director of the Guangdong Provincial Key Laboratory of Virology, the executive director of the Foshan Institute of Pathogenic Microbiology, and the biomedicine  Head of Jinan University .....
Wu Jianguo was born in Xingan County, Jiangxi Province in 1957. He graduated from the Department of Biology of Wuhan University with a bachelor's degree in microbiology in July 1982, and graduated from Wuhan University with a master's degree in virology in July 1985. From 1985 to 1986, he worked at Wuhan University as Lecturer in the Department of Virology, received a Ph.D. in molecular biology from the University of Idaho in 1992, and worked as a postdoctoral researcher in molecular biology at Princeton University from 1993 to 1996. In 2003, he was appointed as the director of the Key Laboratory of Virology of the Ministry of Education; in 2004, he was appointed as the director of the Department of Biotechnology, School of Life Sciences, Wuhan University; from 2004 to 2016, he was appointed as the director of the State Key Laboratory of Virology; in 2016, he was appointed as the pathogen of Jinan University Dean of the Institute of Microbiology; completed the retirement procedures at Wuhan University in June 2019; in 2020, served as the executive dean of the Foshan Institute of Pathogenic Microbiology. He once served as the chairman of Hubei Bioengineering Society, the director of Jinan University Biomedical Industrial Park, and the director of Guangdong Provincial Key Laboratory of Virology.
Wu Jianguo devoted his life to the fields of virology, infectious disease prevention and other biomedicine, especially in the research of virus infection and pathogenic mechanism, virus genetic variation and epidemiology.
The obituary said that even at the last moment of his life, Wu Jianguo remained at the forefront of the prevention and control of major infectious diseases.
According to the WeChat public account of Jinan University, on 7 September 2022, Wu Jianguo's team made new progress in the research on the mechanism of influenza virus regulation of interferon.
On 7 September 2022, the international academic journal PLoS Pathogens published online the latest research results of Wu Jianguo's team from Jinan University. The title of the paper is "Enzymatic independent role of Sphingosine kinase 2 in regulating the expression of type Ⅰinterferon during influenza A virus infection". This study revealed a novel mechanism by which influenza A virus (IAV) infection affects virus replication by regulating type I interferon synthesis through host sphingosine kinase SPHK2.
The study revealed the mechanism by which influenza virus uses the host factor sphingosine kinase SPHK2 to promote its own replication with a very delicate mechanism: After influenza virus infects a host cell, the SPHK2 protein increases in the cell and enters the nucleus, where SPHK2 interacts with HDAC1 , the SPHK2 substrate binding region interacts with TET3 bound to the IFN-β promoter to deacetylate the IFN-β promoter and inhibit the transcription of the IFN-β promoter, thereby inhibiting the synthesis of IFN-β, thereby promoting influenza replication of the virus itself.
The discovery of this mechanism is a further improvement of the functional study of SPHK2, and provides new insights into the molecular mechanism of influenza virus evasion of host immunity, which further broadens our understanding of the interaction between influenza virus and the host.
Professor Wu Jianguo, Associate Professor Chen Jun, Professor Li Hongjian of Jinan University and Associate Professor Xia Chuan of Dalian Medical University are the co-corresponding authors of the paper.
News (19)
Wu Jianguo: Hypoxia signals the presence of covid
In addition, on 7 July 2022, Wu Jianguo's team was invited by Nature's sub-journal "Signal Transduction and Targeted Therapy" and "Signal Transduction and Targeted Therapy" (impact factor 38.104) to write a long review article "Hypoxia signaling in human health and diseases: implications and prospects for therapeutics" was officially published in the journal.
The author summarizes the hypoxia signaling pathways related to important human diseases; expounds the correlation between covid (novel coronavirus pneumonia, COVID-19, Covid-19, covid-19) and hypoxia signaling, and proposes that the hypoxia signaling pathway is closely related to the occurrence of covid; outlines the role of HIF-1α in the occurrence and development of tumors action and mechanism.
Wu Jianguo, a professor at the Institute of Pathogenic Microbiology, Jinan University, and Wan Pin, a researcher at the Foshan Institute of Pathogenic Microbiology, are the co-corresponding authors.
News (20)
Wu Jianguo: Deltacron first appeared in South Africa and Botswana
According to the Southern Metropolis Daily, on 26 April 2022, "Signal Transduction and Targeted Therapy", a sub-journal of Nature, published the latest important findings of the team of Professor Zhang Qiwei and Professor Wu Jianguo on the Omicron variant of SARS-CoV-2. This study found for the first time that multiple cross-variant genes occurred between the Ormicron variant and Variants of Concern (VOC) / Variants of Interest (VOI) strains such as Alpha (Alpha), Beta (Beta), and Delta (Delta). An important mechanism of recombination, it is speculated that the recombinant "Deltacron-like Variant" produced by the Omicron and Delta strains has appeared in South Africa and Botswana as early as November 2021.
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