Springer Nature's "Nature-Microbiology" published a medical research paper on 26 October, pointing out the immune response to SARS-CoV-2 (CCP virus) will decrease over time. This research has improved people's understanding of how the body responds to the CCP virus, and has great significance for vaccine design and disease management.
The paper said that people infected with the CCP virus are known to have an immune response to the virus, but the duration of this response and the length of time it protects individuals are unclear.
The corresponding author of the paper, Katie Doores, King's College London, UK, and colleagues conducted a 3-month study on the antibody response of 59 infected persons and 6 medical staff after they developed symptoms.
They found that the antibody response peaked about 1 month after the onset of symptoms and then began to decline. Severely infected people have the strongest antibody response. Although this response will gradually weaken, neutralizing antibodies can still be detected more than 60 days after the onset of symptoms. Infected persons with mild symptoms can also produce an immune response, but the response is weak and will be reduced to baseline standards. For example, some medical staff have no detectable immune response during the same follow-up period.
This study shows that patients with severe infections of covid can get longer protection than those with mild infections, and the dynamics of this immune response is similar to other local seasonal coronaviruses. The author of the paper said that the vaccine must be able to induce a strong and long-lasting immune response similar to that produced in the body of a severely infected person, and it may also require a strengthening needle to provide long-term protection.
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