Research, editing : Gan Yung Chyan, KUCINTA SETIA
Some cells infected with SARS-CoV-2 (novel coronavirus, covid virus, covi) covid seem to 'explode', scientists have discovered, which may help them create radical new treatments to tackle the virus.
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Fiery cell death (pyroptosis) occurs in most severe covid patients
The reaction, a cell death known as pyroptosis which is linked to inflammation, is thought to occur in roughly eight out of ten patients hospitalised with covid, and may explain how the covid virus can cause such serious damage to lungs and other organs.
Researchers found that when the immune system tries to expel the virus, it can release dangerous particles into the bloodstream which can trigger inflammation in vulnerable parts of the body.
A similar phenomenon called a cytokine storm – when the immune system releases too many infection-fighting proteins called cytokines which then attack healthy tissue – has long been known to cause severe damage in response to covi infection, often leading to multiple organ failure.
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Discovery of the impact of pyroptosis could lead to radical ways to fight covi
However, the landmark discovery of the impact of pyroptosis on severe covid could open up the possibility of new treatments for the disease aimed at stopping the process rather than targeting the virus.
"Inflammation and cell death are both important factors in severe covid, and our research shows pyroptosis is often the culprit,' says Dr Gautam Mehta, consultant hepatologist at the Royal Free Hospital in North London where the study was conducted in conjunction with Boston Children's Hospital.
"It's a major finding because currently our covid treatments are geared towards the virus itself. If we can target the process that causes the severe disease, we could develop an effective treatment which works even in patients for whom the vaccines are not effective."
News (5)
Pyroptosis often observed in severe liver disease patients
Pyroptosis – which means a fiery cell death – is often observed in patients with severe liver disease. Problems begin when bacteria leak from the gut into the liver.
Sensing danger, the immune system sets off pyroptosis in the liver cells. When the cells explode, they release chemicals that the immune system then attacks, leading to liver failure.
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Drugs that tackle pyroptosis could be repurposed to fight covi
There are several drugs which are believed to tackle pyroptosis, including disulfiram, used to treat alcohol abuse, and dimethyl fumarate, often given to patients with multiple sclerosis.
"These are drugs which could easily be repurposed," says Dr Mehta. "They're affordable and available around the world."
News (7)
Diagnosed with no antiviral drugs? The doctor pushes a product "available in Taiwan" to reduce the death rate by 40%
Editor : Zhou Jiaru / https://news.tvbs.com.tw/life/1792688
The domestic epidemic in Taiwan is severe, and the number of confirmed diagnoses is soaring, which makes many people quite worried about what to do if they can't get the medicine. Su Yifeng, a thoracic intensivist, shared that the confirmed patients can use "this drug", which can reduce the mortality rate by 40%, and all hospitals and pharmacies in Taiwan are not out of stock.
Su Yifeng pointed out in a Facebook post that in case people are unfortunate enough to be diagnosed, and because they do not meet the conditions, they will be panicked if they cannot get treatment drugs. "What should I do if I can't get antiviral drugs?" A review of studies found that patients diagnosed with NAC may be able to use the phlegm-reducing drug NAC, which may reduce the mortality rate by 40%.
Su Yifeng also said that at present, there is no shortage of this drug in all hospitals and pharmacies in Taiwan, and the price sold in Taiwan is very cheap, only NT$2 or NT$3 per piece, and the popularity rate is very high. In addition, Su Yifeng also posted related website information pointed out that the use of high doses of this drug in critically ill patients can also improve the oxygen concentration in the blood.
News (8)
Home doctors recommend "these drugs" to relieve 8 mild symptoms during home care
Reporter : Wang Xinyi / https://news.tvbs.com.tw/life/1792727 
The domestic epidemic is heating up, and many people are taking care of themselves at home after being diagnosed. Except for those who apply antiviral drugs, if the average person is diagnosed and has not received the medicine, what medicines can they buy to relieve discomfort? Home physician Xu Shuhua shared several medicines that people with mild symptoms can use, including medicines that can relieve fever, sore throat, headache, cough symptoms, and nasal congestion.
Xu Shuhua said that these recommended drugs are mainly symptom-relieving drugs, because the actual symptoms of many mild cases are mostly upper respiratory symptoms, including fever and very sore throat. Xu Shuhua said that at present, "home isolation" and "self-epidemic prevention" or "home quarantine" are positive for quick screening, and antiviral drugs can only be applied if they meet certain qualifications. Therefore, a few familiar drugs are listed, and the public can also choose similar drugs, but remember to choose a big brand.
Fever, sore throat, headache, muscle aches
Acetaminophen (Punaton, Paramol, Depyretin, PARAN, Acetal, etc.)
‧The usual dose is 500mg/capsule, use one tablet every 4~6 hours, the maximum daily dose is 8 tablets, take it after meals.
‧It is recommended to use it if the ear temperature exceeds 38 degrees, and other pains are also acceptable.
NSAID (Non-Steroidal Anti-inflammatory Drug) class of drugs
‧Ponstan film-coated tablets for pain relief (500mg), 1 tablet for 8 hours, maximum dose of 3 tablets, take after meals.
‧ Naposin Tablets (250mg), maximum dose of 5 tablets per 6~8 hours, take after meals.
‧Ibuprofen tablets (400mg), 1 tablet maximum dose of 8 tablets in 4~6 hours, take after meals.
‧It is recommended to use when the ear temperature exceeds 39 degrees, or when the fever cannot be relieved by using Acetaminophen.
‧Attention: May increase gastrointestinal bleeding.
Cough (Choose one of the following, it can be used with medicine, some require a doctor's prescription)
Dextromethorphan main cough medicine ingredient
‧ Regrow (60mg), once in the morning and evening, one tablet at a time, after meals.
‧ Medicon (15mg), once in the morning, noon and evening, one tablet at a time, after meals.
‧ Medicon-A Miikekang Compound Capsule (20mg), once in the morning, noon and evening, one tablet at a time, after meals.
‧Noscapine tablets (20mg), once in the morning, noon and evening, one tablet at a time, after meals.
‧Cough mixture antitussive and expectorant, once in the morning, noon and evening, 5-15ml each time, after meals.
‧Brown mixture licorice cough water, once in the morning, noon and evening, 5ml each time, after meals. (requires doctor's prescription)
The phlegm is very thick and thick (choose one of the following two ingredients to use)
Contains Ambroxol
‧Mubroxol Calming Phlegm Tablets (30mg), once in the morning, noon and evening, one tablet at a time, after meals.
‧Musco Cough (30mg), take one tablet in the morning, noon and evening, after meals.
‧Mucosolvan (30mg), once in the morning, noon and evening, one tablet at a time, after meals.
Contains Acetylcysteine
‧Actein Aiketan Foaming Tablets (500mg), once in the morning and evening, one tablet at a time, after meals, soak in water.
‧Actein Aiketan Granules (200mg), once in the morning, noon and evening, one sachet at a time, after meals.
Nasal congestion and runny nose (choose one of the following drugs and use it)
‧ Chlorpheniramine maleate 4mg, take one tablet in the morning, noon and night before going to bed, after meals.
‧ Dex-CTM (Teximin) 2mg, once in the morning, noon and night before going to bed, one tablet at a time, after meals.
‧ Cyproheptadine (Pilian) 4mg, once in the morning, noon and night before going to bed, one tablet at a time, after meals.
Second-generation antihistamines, moderately effective, but less drowsy
‧Fexofenadine (Allegra) 60mg, once in the morning and evening, one tablet at a time, after meals.
‧Loratadine (Finska Rotadine) 10mg, once in the morning, one tablet at a time, after meals.
‧ Cetrizine (Cetia Changning) 10mg, one tablet at a time before going to bed.
Third-generation antihistamine (Antihistamine), less effective, but the least drowsy
‧ Levocetirizine (xyzal) 5mg, once before going to bed, one tablet at a time.
Xu Shuhua reminded that you must go to the pharmacy to buy medicines, and you must have a pharmacist's consultation. As for some medicines that require a doctor's prescription, you can ask the pharmacist. This is an adult prescription, not suitable for children under the age of 18.
News (9)
A 2-year-old was diagnosed and died within one day. Luo Yijun revealed that the cause of death was "complicated with acute encephalitis and multiple organ failure"
Reporter : Ye Weichen / https://news.tvbs.com.tw/life/1792931
The Central Epidemic Command Centre announced on 15 May 2022 that there were 68,732 new confirmed cases and 19 deaths in Taiwan. In addition, a 2-year-old child in Keelung died on the same day. The time sequence of death emphasizes that treatment was given and there was no delay in the process. In addition, the cause of death of the child was the diagnosis of covi combined with acute encephalitis and multiple organ failure. However, since the information has not been uploaded, the summary of medical records and the diagnosis of death will be reviewed to incorporate daily deaths.
Luo Yijun, deputy head of the medical response team, said that he had made a preliminary understanding with the hospital and the health bureau. The child was diagnosed with a non-family caregiver who had been in contact with him. In the afternoon of 12 May, his family took him to the emergency department of Keelung Hospital, and he was at home. He had a positive rapid screening test and had symptoms of cough and runny nose. At that time, his body temperature was 36.5 degrees, and his blood oxygen concentration was normal. He did not need oxygen.
Fever, convulsions, and poor mobility began on 13 May 2022. In the evening, the family notified the 119 ambulance and sent him to the emergency room of Keelung Hospital. The inspection time was 19:43. The highest temperature in the hospital was 42.4 degrees. He had rapid breathing and rapid pulse. A pediatric specialist consultation was arranged. He was suspected of viral encephalitis and was recommended to arrange transfer. Contact the Health Bureau to help find a hospital that can treat children with severe illness. There are few beds, so he was transferred to Beirong. At 11.56 pm, an ambulance and a nurse were arranged to assist in the transfer.
News (10)
What should I do if a child under 2 years old is quickly screened covid-positive? "2-step diagnosis" is exempted from hospital PCR
Editor : Zhou Jiaru / https://news.tvbs.com.tw/life/1792930
The domestic epidemic is severe, and the number of confirmed cases continues to rise, and many people are quarantined at home. Luo Yijun, deputy head of the medical response team of the command centre, said on 15 May that if a "child under 2 years old" is diagnosed at home during home isolation, self-epidemic prevention and home quarantine, the diagnosis can be confirmed by a doctor and both parties agree. Then go to the hospital for PCR test.
Luo Yijun explained that although there are no suitable rapid screening reagents for children under the age of 2 in the Republic of China, some parents use the methods or reagents at hand to take tests. or consult the doctors for confirmation. If the quick screening results reach the consensus of both parties to determine the diagnosis, there is no need to go to the hospital for PCR, and ask the doctor to upload the result report according to the process, so as to respect the doctor's discretion and reduce the need for children and parents to rush to the hospital for inspection.
News (11)
Russian oligarch reveals Putin suffers from blood cancer and underwent surgery just before sending troops to Ukraine
Editor : Liu Zheqi / https://news.tvbs.com.tw/world/1792763
The British "Thames" pointed out on the 14th local time that Russian President Vladimir Putin is very likely to suffer from blood cancer. According to the recordings released by the American magazine "New Lines", in mid-March, a Russian emerging consortium oligarch with close ties to Putin talked about Putin's health when talking with Western investors.
According to the report, the unnamed oligarch revealed in the recording that Putin had undergone back surgery related to blood cancer on the eve of the "special military operation" he ordered against Ukraine on 24 February. He also criticized Putin's move to send troops this time, which completely destroyed the economies of Russia, Ukraine and other countries. All oligarchs are eager for "Putin to pass away as soon as possible." He also said the problems lay in Putin's head, accusing "a mad man can turn the world upside down."
Kyrylo Budanov, director of the "General Intelligence Service" (GUR) of the Ukrainian Ministry of Defense, also pointed out in an exclusive interview with the British media on 13 May that Putin's current condition is quite poor, whether it is mental or physical. Including cancer, he now suffers from many diseases at the same time and is very ill but he did not cite any relevant evidence.
Image : Putin's face was swollen and his hands were always clutching the edge of the table before he went to Ukraine. (Photo/Retrieved from the Kremlin website)
After the start of the Russian-Ukrainian war, Putin's health continued to be the focus of attention. During the military parade on Victory Day on 9 May 2022, some media pointed out that he was covered with a thick blanket to keep warm and that there was something wrong with the way he walked. When he met with Russian Defense Minister Sergei Shoigu a few days ago, he was hunched over and slumped on a chair, clutching the edge of the table, in a rather weird posture.
See also: https://www.newsmax.com/world/globaltalk/ukraine-kyrylo-budanov-putin-russia/2022/05/14/id/1069864
News (12)
Expert: Mao Zedong can't clear schistosomiasis, Xi Jinping can't clear covid
Editor : Wen Hui / https://www.ntdtv.com/gb/2022/05/15/a103428962.html
The ever-mutating CCP virus (novel coronavirus, covi) is currently spreading in many parts of China. Experts believe that Mao Zedong, the leader of the Communist Party of China, could not eradicate schistosomiasis in the past, and Xi Jinping's epidemic prevention is now difficult to achieve.
Wang Weiluo, a Chinese water conservancy expert, recently published an article in the "Yibao" entitled "Mao Zedong's Elimination of Schistosomiasis and Xi Jinping's Epidemic Prevention Clearance". The article analyzes that Mao Zedong once launched the "clearing" of sparrows and schistosomiasis, leading to a famine of tens of millions people that starved to death but schistosomiasis has not disappeared in China. It can be seen from this that the current epidemic prevention and control of CCP President Xi Jinping will not work.
The article said that on 16 September 953, Mao Zedong learned that the epidemic situation of schistosomiasis in southern China was very serious, and immediately instructed the then Secretary-General of the State Council, Xi Zhongxun, to take charge of it. Xi Zhongxun is Xi Jinping's father.
Wang Weiluo believes that there are indeed similarities between Xi Jinping's current epidemic prevention and eradication of schistosomiasis and Mao Zedong's past efforts to eliminate schistosomiasis. For example, both of them emphasized personal command and deployment; established a direct central leadership group; and raised them to the level of political tasks.
He said that other similarities between Xi Jinping and Mao Zedong to clear up and eliminate schistosomiasis include: shutting down cities everywhere at all costs, advocating the leadership of the Communist Party and the superiority of the socialist system, giving full play to the institutional advantages of concentrating on major events, and giving full play to the power of the masses.
The article believes that both Xi Jinping and Mao Zedong attach great importance to the role of traditional Chinese medicine. During the eradication of schistosomiasis, Zhejiang, Jiangsu, Anhui, Hubei, etc. have successively developed herbal medicines for killing insects; Not accepted by the rest of the world.
The author said that from 1958 to 2022, over the past 60 years, schistosomiasis has never been eradicated in China. Similarly, Xi Jinping's goal of clearing the disease cannot be achieved because the covid virus cannot be completely eliminated.
News (13)
North Korea says the number of cases has increased by 500,000, Kim Jong-un will imitate the CCP's zero-covid policy
Reporters : Li Qingyi and Lin Yi / https://www.ntdtv.com/gb/2022/05/14/a103428794.html
North Korean state media announced on 14 May that more than 500,000 cases of covi infection and 21 new deaths were reported, and that Kim Jong Un said he would adopt the CCP model to fight against the virus outbreak.
According to the Korean Central News Agency (KCNA), "the number of people with fever from the end of April to 13 May exceeded 524,440." A total of 27 people died. Experts say (CG: Cheung Seong-chang, a North Korea expert at the Sejong Institute in South Korea), it is not an exaggeration to call all these fever cases positive, given North Korea's lack of testing capacity. He estimated that the actual number of virus infections in North Korea may be higher.
On Saturday, North Korean leader Kim Jong Un declared that the outbreak had caused "tremendous unrest" across the country. He also announced that he would adopt the CCP model to fight the virus. However, experts believe that North Korea does not have the capacity to conduct mass testing of its citizens. Facts have proved that the CCP's extreme "zero-covid" policy has been questioned and sparked mass protests.
Two days ago, on 12 May, Pyongyang announced that it had found a positive case of the Omicron BA.2 variant and found its first death. As early as January 2020, North Korea closed its borders and closed the country immediately after the outbreak in Wuhan, but it was unable to stop the epidemic. This also makes the outside world question, and it is futile to close the city and clear it.
News (14) to (18) / Report by : Yang Ning / Editor : Liu Mingxiang / https://www.ntdtv.com/gb/2022/05/14/a103428618.html
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News (20)
Finland formally announces bid to join NATO despite Putin's threat
Reporter : Chris Jewers, Daily Mail / https://www.dailymail.co.uk/news/article-10818029/Finlands-president-formally-announces-bid-join-NATO-despite-Putin-threat.html / Image : Reuters
President Sauli Niinisto and Prime Minister Sanna Marin made the announcement at a joint news conference at the Presidential Palace in Helsinki.
The Finnish Parliament is expected to endorse the decision in coming days, but it is considered a formality following a swell in public support for doing so.
A formal membership application will then be submitted to NATO headquarters in Brussels, most likely at the some point next week.
Sweden's governing party also plans to announce its position on seeking NATO membership later today.
The two nonaligned Nordic nations becoming part of the alliance would pose an affront to Russian President Vladimir Putin, who has justified the war in Ukraine by claiming it was a response to NATO's expansion in Eastern Europe.
Finland shares a 830-mile border with Russia. Should Finland's application be ratified, Russia's border with NATO would roughly double in length.
Yesterday, Putin told the President of Finland he is making a "mistake" by joining NATO as it faces "no security threats" in a phone call.
President Niinistö said his conversation with Putin was "conducted without aggravations" as both parties worked to "avoid tensions".
Russia's invasion of Ukraine and cyber-attacks on Finland and Sweden have "altered the security environment" in Helsinki, Putin was told.
Meanwhile, Western military officials said Sunday that Moscow's campaign in Ukraine, believed to have been launched with the goal of seizing Kyiv and toppling the Ukrainian government, had slowed to a snail's pace. They said the invading Russian army had lost up to one-third of its combat strength since February.
Today, the President of the Republic and the Government's Foreign Policy Committee have jointly agreed that Finland will apply for NATO membership, after consulting parliament. Niinisto said, "This is a historic day. A new era is opening."
"We have reached today an important decision in good cooperation with the government and the president of the republic. We hope the parliament will confirm the decision to apply for the NATO membership during the coming days. It will be based on a strong mandate", Prime Minister Sanna Marin said.
Finland has remained militarily non-aligned for 75 years but after its powerful eastern neighbour invaded Ukraine in February, political and public opinion swung dramatically in favour of membership, with the Finnish president and prime minister on Thursday calling for the country to join NATO "without delay".
Russia has repeatedly warned of consequences if Helsinki joins the alliance, but earlier this week, Niinisto told reporters that "joining NATO would not be against anyone." He said his response to Russia is: "You caused this. Look in the mirror."
NATO's deputy chief said on Sunday that the alliance is confident that it can overcome objections by Turkey and quickly admit Finland and Sweden.
Foreign ministers from NATO's 30 member states are holding two days of talks this weekend in Berlin that are focused on the two Nordic countries' membership bids.
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https://www.youtube.com/watch?v=aIxbBSodBeI
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