Senate may re-determine Georgia, Arizona governor
The current Senate election is still unclear, and the final attribution will depend on three key battleground states. In addition, the race for the governorship of Arizona remains stalemate.
Georgia Senator Warnock: "Are you ready to do it again?"
The state of the U.S. Senate may once again be decided in Georgia, as if a repeat of the election two years ago.
Georgia had 99 percent of the vote as of Thursday afternoon, with incumbent Sen. Raphael Warnock narrowly leading Republican challenger Herschel Walker by 0.9 percentage points (49.42 percent: 48.52 percent).
According to Georgia election rules, if neither candidate gets 50 percent of the vote, a second runoff will be held.
Georgia Secretary of State Brad Raffinsperger: "Our state's election will be a runoff on December 6, Senator Warnock against Walker."
At present, the Republicans have won 49 seats in the Senate, the Democrats have won 48 seats, and three seats are still pending due to the unfinished vote count. (Georgia, Arizona, Nevada)
Arizona's election is now more Democratic. With 70 percent of the votes cast, incumbent Senator Mark Kelly won 51.4 percent of the vote, nearly five points ahead of Republican challenger Blake Masters (46.4 percent). Arizona, once a Republican stronghold, has turned into a swing state in recent years.
In Nevada, with 83 percent of the vote cast, Republican challenger Adam Laxalt has 49.4 percent, nearly 1.8 percentage points ahead of incumbent Sen. Catherine Masto. It is expected to reverse this seat.
For Republicans to regain control of the Senate, they must win at least two of the three remaining seats.
US President Biden: "We lost fewer seats in the House of Representatives than any Democratic president in the past 40 years has lost in midterm elections."
In the House of Representatives, the Republicans, while underperforming as expected, are still expected to regain their majority. As of Thursday afternoon, Republicans had won 209 seats, just nine short of the 218-seat majority.
As for why the previously expected "red wave" did not appear, some analysts pointed out that the election of Democratic candidates in various places was boosted by the issue of abortion. However, a Republican-controlled House of Representatives will still hinder the administration of the Biden-Harris administration for the next two years.
U.S. House of Representatives Republican leader McCarthy: "Americans are ready for a majority that offers a whole new direction."
On the governor's side, all eyes are on Arizona. With 70 percent of the votes cast, the state's Republican candidate Kari Lake is less than 1 percentage point behind Democratic candidate Katie Hobbs. (Cary Lake 49.56%: Katie Hobbs 50.44%)
On Election Day, voting machines in Arizona's most populous county, Maricopa County, malfunctioned, and county officials said about 20 percent of polling centers experienced tabulation issues that delayed ballots and sparked outrage and some disputes.
Arizona Republican gubernatorial candidate Kari Lake: "When victory comes, we'll take it, we'll turn it around."
Lake, who never held public office, but has long worked in the media is well known in Arizona; Hobbs is Arizona Secretary of State. The pair's rivalry on campaign philosophies also reflects the polarization of Arizona's politics in recent years.
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Colorado Republican Rep. leads in re-election bid
On 10 November, Colorado Republican Rep. Lauren Boebert took the lead in the re-election process on the 8th.
Bobert, 35, currently leads Democrat Adam Frisch by about 450 votes, according to unofficial results from Colorado Secretary of State Jena Griswold.
Bobbert, a staunch supporter of former President Donald Trump, is seeking a second term.
"Win!" she said on Twitter after the latest results were announced.
Frisch had a 64-vote lead late in the 9th.
"As expected, this (election) is coming to an end. Thank you for your tireless support! We feel great and will keep going. We feel great and will make sure every valid vote is counted. ", Frisch said before the latest results. "Let's go to the end and beat Lauren Bobert."
Frisch, 55, is a businessman and former Aspen city council member.
Before taking office, Bobert was a staunch supporter of the Second Amendment, challenging former Rep. Beto O'Rourke, D-Texas, on gun issues. She also used to own a restaurant called Shooter Grill, where waitresses would wear guns in holsters.
Colorado was one of the states that failed to count every vote within 24 hours after polling places closed. As of now, there are still some votes waiting to be counted.
Pueblo County Clerk Gilbert Ortiz said on the 10th that there are still about 5,000 mail-in ballots and 1,800 in-person ballots to be counted; another 600 absentee ballots are possible. considered a valid ballot.
Ortiz told The Epoch Times that officials in Pueblo County expected to complete the count by the end of the day.
Lyn Scott, the Otero County clerk, said there are about 100 more ballots to be counted there.
Securing Bobbert's seat would help the GOP flip and take control of the House.
At press time, the Republicans had won 210 seats, compared with 193 for the Democrats. Republicans flipped seven seats on a current basis.
In another tight race in Colorado, Democrat Yadira Caraveo, who represents the state's eighth congressional district, and Republican Barbara Kirkmeyer are within a few inches of each other 150 votes.
Calavio, 41, is a state representative. Kirkmeier, 64, is a state senator.
Colorado's Eighth District is a new district that saw a significant increase in the state's population in the 2020 census.
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These two Arizona counties will be decisive
Reporter : Li Xin / Editor : Ye Ziwei / https://www.epochtimes.com/gb/22/11/10/n13863648.htm /
Image : The Mid-term Election tally is still not complete. An election worker scans mail-in ballots at the Maricopa County Tabulation and Election Center in Phoenix, Arizona, on 7 November 2022. (Justin Sullivan/Getty Images)
Arizona's governor and senator election results have not yet been released, the current gap between the two governor candidates is even less than one percentage point, and there are still Hundreds of thousands of votes are yet to be counted. The results of the counts in some key regions may decide who will be the final winner.
According to data from the US political news website "Politico", as of 8:06 p.m. ET on Thursday (10 November), Arizona Democratic gubernatorial candidate and current Secretary of State Katie Hobbs Katie Hobbs edged ahead with 50.6 percent of the vote, while former President Trump-backed candidate Kari Lake, a former TV news anchor, won 49.4 percent of the vote. . The turnout rate at this time is about 71%, and there are still a large number of votes that have not been counted.
The state's Senate race is also inconclusive, although incumbent Mark Kelly currently holds a roughly 5-point lead over Republican candidate Blake Masters.
Over the next few days, eyes will turn to election officials in some counties, as the remaining nearly 30 percent of the votes will determine where governorships and Senate seats go.
The vast majority of Arizona's 15 counties have yet to report some of their votes, but two counties are particularly important, accounting for a sizable share of the remaining votes, according to The New York Times. Maricopa County and Pima County.
Maricopa County
Maricopa County, which includes Phoenix and much of the surrounding area, usually gets a lot of attention in the state's elections due to its size, and this year was no exception.
Maricopa is the state's largest county and accounts for nearly 62 percent of Arizona's population, according to U.S. Census Bureau estimates.
Former President Trump won Arizona in 2016, leading by 3 points in Maricopa County. Four years later, he narrowly lost to Biden in the state and trailed by 2 points in the county.
Officials in Maricopa County estimated Wednesday that about 428,000 ballots have yet to be counted, almost all of which will be counted Friday night.
Republicans had tried to extend voting hours in the county during an emergency court hearing on Tuesday night, but a state judge denied the motion as about 20% of the county's polling stations had tabulator malfunctions on Election Day, saying it has seen no evidence that someone has been denied the opportunity to vote.
At an election night rally, Lake accused election officials of "incompetence."
Maricopa County officials said Thursday that more election results will be released at 10 pm ET.
Pima County
Pima County, located in southern Maricopa County, is home to about 14 percent of Arizona's population and is the second-largest county in the state by population.
The county has reported 63 percent of the vote, a number that lags behind all other counties in the state, according to an estimate by The New York Times.
Pima County has historically leaned toward the Democratic Party. Biden won the county by 19 points in 2020, and Hillary Clinton won the county by 13 points before 2016.
As of Thursday morning, Hobbs and Kelly led by 20 and 24 points, respectively, in Pima County.
Combined, the remaining votes in Maricopa and Pima counties account for roughly 62 percent of the state's remaining votes, according to an Associated Press estimate.
Pima County recorder Gabriella Cázares-Kelly told reporters that the Pima County vote count could continue into next Monday or next Tuesday.
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After the U.S. mid-term elections, scholars: Or tougher to counter the CCP
After the mid-term elections in the United States, Taiwanese scholars expect that in the future, the Biden-Harris administration will fight the CCP harder and support Taiwan in a friendly way. Let's take a look at the analysis.
Qiu Shiyi, a professor at the Department of Politics at Tunghai University: "The closer we get to 2024, the clearer the strategy of the entire U.S., China, and Taiwan. There is absolutely no room for concessions, and it will become more and more clear."
The National Policy Research Institute held a symposium in Taipei on the 10th. Scholar Qiu Shiyi said that the consensus of experts and scholars is that opposing the CCP is an irreversible trend; Lin Zhengyi believes that the election will not fundamentally change Biden’s foreign strategy and China policy, and the CCP’s technology containment and semiconductor ban will be important trends; the House of Representatives In the future, there will be more criticism of Biden's policies and questioning of weakness towards the CCP.
Lin Zhengyi, a researcher at the European and American Institute of the Academia Sinica: "The Republican Party controls not only the speaker, but also the chairmen of various committees. They will have relatively big and slightly tough policies on China issues."
Su Ziyun, Director of Strategy and Resources of the National Defense Security Agency: "In a situation where the Republican Party has become a limited majority, President Biden has not made him truly lame because of Congress, but he is only constrained in internal affairs, so he maintains such an inertia in diplomacy."
Wang Hongren, deputy executive director of the National Policy Research Institute: "What version of the Taiwan Policy Act will be used in the next session? What form will it be in? How quickly will it be passed? And what kind of response will China have? U.S.-China political relations for at least two years into the future.”
Wang Hongren observed that American voters have a growing sense of threat from the CCP, but when the more powerful Xi Jinping confronts the weaker leader Biden; Biden’s support has fallen, and many issues such as inflation in internal affairs are urgently dealt with, and there are differences of opinion in society, and Biden may rush forward in strategy, which may have international effects, and the United States should deal with it carefully.
However, Su Ziyun pointed out that it may be due to the political tradition of the CCP, the leaders of the CCP seize all kinds of power, and it is easy to make mistakes.
Su Ziyun, Director of Strategy and Resources of the National Defense Security Agency: "He is the commander-in-chief in everything. This is a bit like the mistake made by Hitler's Nazi Party during World War II. Hitler held too many positions and commanded too carefully. It is easy to cause fatal confusion and mistakes in decision-making.”
Disease control
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SARS-CoV-2 changes the RNA of infected cells for the first time
According to a report by the Physicist Organization Network on the 9th, scientists from the Federal University of Sao Paulo (UNIFESP) in Brazil have obtained the first time analysis of 13 data sets obtained by studying the RNA of viruses, human and animal cells. It has been shown that SARS-CoV-2 (covi) changes the function of host cell RNA. Related papers were published in the latest issue of the journal Frontiers in Cell and Infection Microbiology.
In this study, a research team from UNIFESP examined the epitranscriptomes—the collection of cellular RNA biochemical modifications such as methylation—of monkey-derived Vero cells and human-derived Calu-3 cells by direct RNA sequencing. . They qualitatively demonstrated changes in the RNA of infected cells by analyzing all RNA present in the cell, locating the amount of methylation in each region of the nucleotide.
"Our first important finding in this study is that infection with SARS-CoV-2 increases the level of m6a (N6-methyladenosine) concentration, a type of methylation in host cells, compared to uninfected cells," said Maseru Brionis, author of the paper.
The researchers explain that m6a is the most common type of RNA nucleotide modification and is involved in several important processes such as intracellular localization and protein translation. Methylation is a biochemical modification that changes the behavior of proteins, enzymes, hormones and genes. "Within viruses, methylation serves two functions: regulating protein expression, and protecting the virus from the effects of interferon, a potent antiviral substance produced by the host."
The team also found differences in the sequence of nitrogenous bases in the nucleotides of the different strains. "Some strains may be more methylated than others. If so, they can proliferate better inside host cells," Brionis said.
Having completed their study of how SARS-CoV-2 modifies m6A in host cells, the scientists plan to further analyze the stored data to look for correlations between levels of viral RNA methylation and the amount of virus released per infected cell during each viral outbreaks
"The more methylated the virus, the larger the outbreak," Brionis said. "These findings lay the groundwork for research into new treatments for COVID-19 and the repurposing of existing medicines, as well as for a more in-depth study of the virus and learn how virus strains evade the immune system."
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CRISPR personalized therapy has made significant progress——
Gene-edited T-cell cancer treatment begins human trials
Non-viral engineered immune cells can be used for personalized treatment of cancer, a study published in the British "Nature" magazine on 10 November 2022 reported the significant progress of this engineered cell and its impact during human clinical trials. The method uses CRISPR genome editing, a system derived from bacteria, to generate patient-specific T cells with good safety. Although the current clinical benefit of patient response is limited, this study demonstrates the potential feasibility of this treatment strategy.
Harnessing the power of the human immune system to treat cancer is an attractive target. T-cell surface receptors, key parts of the immune system involved in recognizing and responding to specific antigens, can spot cancer cells because a single mutation in a cancer cell's genome alters cell-surface proteins. Isolating these T-cell receptors that can detect cancer cells and using them to generate therapeutic T cells could open up a new avenue for treating refractory cancers.
This time, researchers at the University of California and cell therapy company PACT Pharma have developed a method that uses the CRISPR-Cas9 genome editing system to insert cancer-specific T cell receptors into T cells of cancer patients, thereby generating personality. anticancer immune cells.
In a phase I clinical trial, 16 patients with metastatic solid tumors (mostly colorectal cancer) that had not responded to standard therapy were treated with genetically engineered T cells that express personalized T cells that target individual cancer mutations. cell receptors. Of the 16 subjects, the therapy stabilized 5 and further progressed in 11 others. Only 2 patients experienced adverse effects from T-cell therapy, while all patients experienced the expected adverse effects associated with concurrent chemotherapy.
The team emphasizes that their method has certain limitations, such as the time required to characterize potential antigens and the isolation, cloning, and testing of T-cell receptors, and the varying affinity of patient-specific T-cell receptors to the corresponding antigens. They noted that some processes were optimized during the trial and there is room for further optimization in the future.
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Study finds critical vulnerabilities in major variants of covi
According to a paper published in the journal Nature Communications on 18 August 2022, researchers at the University of British Columbia (UBC) have discovered a critical vulnerability in all major variants of SARS-CoV-2 (covi), including the recently emerged Omicron BA.1 and BA.2 subtypes. This weakness could be targeted with neutralizing antibodies, or pave the way for treatments to tackle all covi variants.
The researchers used cryo-electron microscopy (Cryo-EM) to reveal the atomic-level structure of vulnerable points on the viral spike protein, so-called epitopes. The paper further describes an antibody fragment called VH Ab6, which is able to attach to this site and neutralize each of the major variants.
Antibodies, substances the body produces to fight disease, can be extracted from cells from recovered patients and grown in the laboratory. A professor at the UBC School of Medicine and senior author of the study Dr Brahmaniam said, "Antibody attaches to the virus in a very specific way, like a key goes into a lock. But when the virus mutates, the key doesn't work anymore.We have been looking for a "master key" that will continue to neutralize the antibodies that SARS-CoV-2 has undergone, even after extensive mutations."
The "master key" identified in the new paper is the antibody fragment VH Ab6, which has been shown to be effective against SARS-CoV-2 Alpha, Beta, Gamma, Delta, Kappa, Epsilon, and Omicron variants. The fragment neutralizes covi by preventing the virus from entering human cells by attaching to an epitope on the spike protein.
Dr Subramaniam said the study revealed a weakness that was largely unchanged among the different variants of the virus and could be neutralized by antibody fragments. This critical vulnerability can now be exploited by drugmakers, and the resulting treatments may be effective against existing or even future covi variants, or will be a game-changer in the ongoing fight against the virus.
News (11)
Notice on Inclusion of Azvudine Tablets in the Novel Coronavirus Pneumonia (Covid) Diagnosis and Treatment Program
All provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps Health Committees and Administration of Traditional Chinese Medicine:
According to the approval opinion of the State Food and Drug Administration on the conditional approval of the registration application of Azvudine Tablets for the treatment of covid, in order to further improve the antiviral treatment plan for new coronavirus pneumonia, the drug was included in the "Novel Coronavirus Pneumonia" treatmenmt plan after research. Novel Coronavirus Pneumonia (Covid) and Treatment Program (Ninth Edition) details as follows:
1. The name of the drug
Azvudine tablets.
2. Indications
For the treatment of adult patients with common novel coronavirus pneumonia (COVID-19).
3. Usage and dosage
Swallow whole tablet on an empty stomach, 5 mg each time, once a day, and the course of treatment should not exceed 14 days.
Fourth, matters needing attention
It is not recommended for use during pregnancy and lactation, and it should be used with caution in patients with moderate to severe hepatic and renal impairment.
Before using this drug, you should read the "Azvudine Tablet Instructions" approved by the State Food and Drug Administration, and use the drug correctly according to the indications, usage and dosage specified in the instructions. Patients should take medication under the guidance of a physician. Before prescribing the drug, physicians should be familiar with contraindications, adverse reactions, drug interactions, etc., and inquire about the patient's drug allergy history in detail, so as to avoid the use of patients with contraindications. All localities should strictly follow the requirements of the "Administrative Measures for the Reporting and Monitoring of Adverse Drug Reaction", and do a good job in monitoring and reporting adverse drug reactions to ensure drug safety.
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