Thursday, July 29, 2021

Side-effects of MVC-COV1901 vaccination during a clinical trial vs other vaccines

Translation, editing : Gan Yung Chyan, KUCINTA SETIA

Translation of external news on Taiwan and disease control

News (1) to (7) / Editor : Hu Mengxin 


News (1)

Look at the advantages and disadvantages of vaccines! MVC vaccine subjects exposed: The second dose of side effects 

Since 27 July, the registration and appointment system for COVID-19 vaccine intentions in Taiwan has officially included MVC-COV1901, the MVC vaccine option, which is provided to people over 20 years of age. There are community discussions on the side-effects of available vaccines in Taiwan.

News (2)

At least 552,523 people choose MVC vaccine in Taiwan

 According to the latest information from the command centre, as of yesterday (28 July), there are 552,523 people who are willing to choose MVC-COV1901. Commander Chen Shizhong also said that MVC vaccines will be provided as early as August. 

Recently, a netizen posted a post on the Facebook community to reveal his personal experience of voluntarily participating in the second phase of the MVC vaccine test to solve blindness, and at the same time shared his physical condition after vaccination. 


Image : A netizen shared his thoughts on the MVC vaccine in the Facebook community. (Photo/Retrieved from the Facebook of "Booming Waste Commune") 

The Facebook owner "Booming Waste Commune" revealed that he was lucky, because about 14% of the testers in the second phase would get a placebo, and he got a real vaccine. In addition, he also shared the side effects of MVC vaccination.

News (3)

Side-effects of both doses of MVC vaccine, according to a participant of Phase II clinical trial

He said that after the first dose of MVC-COV1901, he had muscle soreness, small red rash on the collarbone and chest area, and slight diarrhea. After the second dose, he took a rest in the hospital for 30 minutes. He had mild headache within minutes, and other side effects were not much different from those of the first dose, and revealed that he thought "the side effects of the second dose were slightly more pronounced than the first dose." 

Some netizens left a message asking how much protection the vaccine brings. In this regard, he said that he had inquired, but the actual message received was that the data was not provided to him for confidential reason. 

Faced with the question of the netizen, he responded that if there was a problem, he would go to other vaccines. When he participated in this experiment, he just wanted to make a contribution. The advantages and disadvantages of each vaccine are different, so special attention should be paid when selecting the preferred vaccine. 

Faced with the selection of vaccines, Lin Shibi, a senior infection specialist at the front desk, published an article on Facebook "Self-Travel Addict in Japan" to analyze the advantages and disadvantages of each vaccine. He said that many people still hesitate to ask for it. AZ vaccine may cause thrombosis and sudden death, and the highly discussed MVC-COV1901, UBI-912 have not done the third phase, can you believe in their EUA?

In this regard, he listed the advantages and disadvantages of the four vaccines to help the public better understand the characteristics of different vaccines. 

News (4)

MVC vaccine: Significantly fewer adverse reactions than other vaccines

Advantages: The neutralizing antibody is relatively higher than the AZ vaccine, and the safety of the protein vaccine is theoretically better, with significantly fewer adverse reactions.

Disadvantages: The full report and EUA meeting minutes are currently "unpublished", and they have not been tested in the third phase, so their protection is uncertain. In addition, there may be problems in the identification of future international vaccine passports. 

News (5)

Moderna: Antibodies it produces are extremely high, men at risk of myocarditis

Advantages: Performance is comparable to Pfizer-BioNTech vaccine/Comirnaty in clinical trials. The neutralizing antibodies it produces are extremely high among current vaccines. 

Disadvantages: The second dose has high adverse reactions, and men under 30 are at risk of myocarditis. Whether the second dose of vaccine is delayed to 10 to 12 weeks will reduce its protective effect. It is still unknown (there is more information on Comirnaty). 

The protection after the first dose of Moderna may be worse than that of AZ. It takes 14 days after the second dose to have the best protection

News (6)

Comirnaty: Men at risk of myocarditis, 14 days after the second dose for the best protection

Advantages: There are far more empirical data than Moderna, and most of the protective power numbers are the best vaccines. 

Disadvantages: The second dose has high adverse reactions, and men under 30 are at risk of myocarditis. The protection after the first dose may be worse than that of AZ. It takes 14 days after the second dose to have the best protection. 

News (7)

AZ vaccine: Most widely administered, higher immunity but side-effects of thrombosis and low platelets


Advantages: The most widely administered vaccine in the world has a large amount of empirical data and has successfully controlled the epidemic in the UK. In terms of preventing severe illness, after 14 days of the first dose, it has a good protective effect. There will be opportunities for mixing vaccines in the future. 

In the Oxford study, AZ mixing Comirnaty has a neutralizing antibody similar to two doses of Comiranty, but has higher cells immunity. 

Disadvantages: The first dose of adverse reactions is high. It is necessary to pay attention to the side effects of thrombosis and low platelets, which occur within 4 to 28 days, about 1 in 100,000.


News (8) to (9) / Reporter : Wang Yihui / Image : Composite Picture (Photographer : Ke Shengxiong)

News (8)

The super combination of vaccine scrambling protection is exposed! Scholars have proposed three MVC mixes to put "this rank" in safety

 

More countries are accepting the strategy of vaccine mixing when the first dose fails to stop the spread of covid. The ACIP expert meeting in Taiwan has agreed to open AZ vaccine mixing mRNA vaccine but when it will open depends on the vaccine arrival volume.

The immunology authority Zhang Nanji suggested to face the variant virus, the third dose of vaccine, the domestic MVC or UBI can be used in the third dose. 

ACIP has recently adopted a consensus that vaccines can be mixed. At present, the first to three types of vaccinations are initially considered. The second dose can be mixed with mRNA vaccines at intervals of more than 8 weeks, that is, if Yongling and TSMC purchased Pfizer-BioNTech vaccine/Comirnaty which can arrive in Taiwan in September as soon as possible, the public will have the opportunity to mix AZ vaccine and Comirnaty in September.

More and more countries are accepting the strategy of vaccine mixing. According to the published study, 830 subjects over the age of 50 were divided into four groups to receive two doses of vaccine. The results found that the neutralizing antibody titer of Comirnaty plus Comirnaty was 14080, the highest, followed by AZ vaccine first. Comirnaty combined with another dose of Comirnaty and AZ vaccine, and for all AZ vaccines, the neutralizing antibody titer is only 1392, which is the lowest.

Huang Yucheng, Physician of Children's Infectious Diseases (ACIP Committee), Chang Gung Linkou, said, "Some data released so far, some clinical trial results come out, because those still have some relatively complete (research). That is the AZ vaccine plus Comirnaty. It seems that the effect is good, and everyone can accept it. I think the first one has a relatively bad reaction to either the AZ vaccine or the Moderna vaccine (after the first dose). For relatively strong adverse reactions, the first one can be mixed. For example, after the AZ vaccine, if the adverse reactions are quite serious, some of them are reported to have adverse reactions, then it is confirmed that it is the next time. At that time, you can consider changing to a new vaccine.”

News (9)

Likelihood of Taiwan opening up mixed vaccinating depends on the status of vaccine arrivals

Huang Yucheng, one of the ACIP committee members, said that when Taiwan will open mixed vaccinating, it still depends on the status of vaccine arrivals. According to current international research, adenovirus vector vaccines and the addition of mRNA vaccine is a powerful vaccine combination. Immunology author Zhang Nanji believes that mixing can also reduce side effects. 

Former Professor Zhang Nanji of the Institute of Microbiology and Immunology at Yangming University said, "Like many of us who have been given the Moderna vaccine recently, they will be allergic to that (excipient) PEG2000. So if you say that you get the Moderna vaccine for the first time if you’re allergic, I suggest you hurry up next time. If you still want to get an mRNA vaccine, you should use Pfizer-BioNTech vaccine (Comirnaty) to get past its side effects. Mixing is basically a basic view of immunology. You want to make a very single high-titer antibody. If you have that antibody, you will always have to change your adjuvant or your carrier." 

Zhang Nanji believes that the third dose will have a chance of life-long immunity, and facing a variant virus like Delta, the third dose is unavoidable. So, he suggested that the first dose can be AZ vaccine or CoronaVac, the second dose can be used with Moderna or Comirnaty, and the third dose should be changed. The protein can be used for Novavax or MVC-COV1901, and UBI-912. The first two doses are mainly international vaccines, and the third dose can be domestically produced. It takes into account the effectiveness and safety of domestic vaccines. It also allows domestic vaccines to be positioned.

However, the WHO said before that mixing is not recommended.  The doctor thinks. Li Jianzhang, clinical professor of the Department of Emergency Medicine at National Taiwan University Hospital said, "My personal judgment is that the reason why the WHO is relatively conservative is that when the Moderna vaccine was originally made, or when the so-called AZ vaccine was first used, it was in the third phase (clinical trials). Neither can see the so-called thrombosis, nor the so-called myocarditis. After it hits millions of people, this thrombosis and myocarditis, you will find that it is really increasing. For the person who is always the slowest to speak, and the person who sees the final data, he made the most stable decision, so this is what I said, you have to make a trade-off with the epidemic situation in your country." 

To deal with SARS-CoV-2, it is possible to stabilize the epidemic by considering the layout of vaccine procurement, the speed of vaccine delivery, mixed purchases, mixed sales, clinical applications, diversified contingency plans and advance deployment assessments.


News (10) to (20) / Source : The Irrawaddy

News (10)

Myanmar Junta placing false hopes in CCP's virus vaccine diplomacy


Image courtesy: Embassy of the People's Republic of China to Myanmar

Air China planes were landing at Yangon International Airport all through the rainy nights last week, bringing in desperately-needed CCP novel coronavirus (SARS-CoV-2, CCP virus, covi) vaccines to the city that is at the epicenter of the deadly third wave of coronavirus in Myanmar.

With hundreds of people believed to be dying daily from COVID-19 (covi) in Yangon, the military regime has struggled to source vaccines from any other country than China, a reflection of how much of the rest of the world regards the junta as an illegitimate government.

So far, Beijing has dispatched three million vaccine doses to Myanmar: two million of the Sinopharm vaccine – donated free by the People's Republic of China (PRC)  – and one million Sinovac vaccines purchased by the regime. The junta has plans to buy two million more doses from Beijing.

Since late 2020, PRC has committed to providing the Chinese Communist Party (CCP)'s endorsed covi vaccines to more than 80 countries under its “Health Silk Road”, a pharmaceutical extension of China’s "One Belt, One Road" Initiative (Belt Road Initiative or BRI).

Dubbed “China’s vaccine diplomacy”, the vaccines have mostly gone to countries already participating in the BRI. Critics claim that Beijing wants those nations to remain indebted to China. As a result, they will continue to support and allow PRC infrastructure and connectivity projects in their countries.

Active temperature control containers carrying China’s vaccines seen at Yangon International Airport on July 23./ Chinese Embassy in Yangon

Myanmar is one of the countries participating in the BRI and Beijing wants to invest in multi-billion dollar infrastructure projects from the country’s north to west. In particular, China craves access to the Indian Ocean via the port of Kyaukphyu in western Myanmar’s Rakhine State, which will enable its ships to avoid passing through the strategic and vulnerable Strait of Malacca.

Myanmar’s covi vaccine program has struggled since the military’s February 1 coup, with millions of civilians refusing the jab and thousands of health workers on strike in protest against military rule. Amid a rapid surge of coronavirus, the regime-controlled Ministry of Health and Sports (MOHS) has repeatedly urged citizens to get the CCP jabs, lauding the efficiency of the vaccine in reducing infection and death rates.

News (11)

Sinopharm 79% effective in preventing symptomatic covid 

China’s Sinovac and Sinopharm vaccines are 50% to 79% effective in preventing symptomatic Covid infection, according to clinical trials across the globe.

News (12)

Thailand, Indonesia and Malaysia engage in mixed vaccinating 

However, those countries in Southeast Asia that have mostly relied on Chinese vaccines – Indonesia, Thailand, Cambodia and Malaysia – are still seeing a spike in infections, despite a high take up by people of the vaccines. Thailand has now changed its vaccine policy and is offering a mix of Sinovac and the British-Swedish AstraZeneca/AZ vaccine.

Indonesia, where 90 percent of the vaccines used in its vaccination program are Sinovac, is now the COVID-19 epicenter of Southeast Asia. More than 30 health workers have died and hundreds more have become infected, despite receiving two doses of the Sinovac vaccine.

Now Indonesia, the largest country in Southeast Asia, has said that heath workers will be given booster jabs of the US-made Moderna vaccine alongside Sinovac shots. Malaysia has also announced that it will stop using Sinovac once its supplies end, saying that it has a sufficient number of other vaccines, including the Pfizer-BioNTech mRNA vaccine, for its vaccination programme.

Those decisions have raised fresh concerns about the efficacy of Chinese vaccines against the more transmissible Delta variant currently sweeping through Myanmar.

In late July, the former deputy director of the China CDC, Dr. Feng Zijian, admitted that antibodies triggered by the two CCP covi vaccines are less effective against the Delta variant compared with other strains. Moreover, a recent study from Hong Kong University found that the antibody level of people inoculated with the Pfizer-BioNTech vaccine/Comirnaty is ten times higher than those generated by the Sinovac vaccine/CoronaVac.

News (13)

CCP only cares about the success of its vaccine diplomacy

However, Beijing appears only to care about the success of its vaccine diplomacy and not about the effectiveness of its vaccines. Four months before the Sinovac vaccine was approved by the World Health Organization (WHO) as safe for emergency use, PRC gave it to some of the ethnic armies who control areas of Shan and Kachin States along the frontier with mainland China.

News (14)

United Wa State and Kachin Army start covi vaccination in late February 2021

The United Wa State Army, Myanmar’s largest ethnic armed group, started its vaccination program in late February, according to an announcement on WeChat. It has vaccinated almost all of its 550,000 population in its self-administered territory that covers six townships across two districts in Shan State.

The Kachin Independence Army has also vaccinated more than 30,000 people in the areas it controls in Kachin State, after receiving vaccines from China from late February on. Beijing was quick to offer vaccines to the ethnic armed groups in Myanmar’s borderlands not only because it has close links with them, but because it is concerned about unvaccinated people moving across the Myanmar-China frontier.

News (15)

Get a CCP covi vaccination or boycott the CCP virus vaccines

Despite the political and health crisis in Myanmar under the military regime, people have mixed reactions to the Chinese jabs. Some have said that they are better than nothing, but others say that they do not want to take Chinese vaccines as a show of resistance against the junta and its ally China, as well as because of the vaccines disputed efficacy.

Anti-China sentiment has risen dramatically since the coup, after China showed its support for the regime. Two think tanks run by Myanmar citizens based in Yangon conducted anonymous online surveys about whether people are willing to get Chinese vaccines under the regime’s vaccination program.

Of the 55,000 people surveyed by one of the think tanks, 90 percent said that they won’t take the Chinese jabs for two reasons. The first reason was that people don’t recognize the regime as the legitimate government of the country. The second was that they do not believe in the efficiency of the Chinese shots and they want to boycott Chinese products, as they believe that Beijing supports the junta.

Another think tank group polled 7,000 people in its survey. Over 87 percent of them would refuse the Chinese vaccines as they mistrust the junta’s vaccination program. All said that they do not trust the efficacy of the Chinese jabs, in part because of their failures elsewhere in the region.

When the Chinese Embassy in Yangon announced that Sinopharm and Sinovac vaccines had arrived in Myanmar, nearly a thousand of Facebook users said that they will not get CCP vaccine jabs. Nevertheless, the regime launched the Sinopharm vaccine in major cities like Mandalay and the capital Naypyitaw, prioritizing people aged above 65.

News (16)

Myanmar TV reports claim school teachers and prisoners in Yangon and Naypyitaw have been vaccinated

TV reports from regime-controlled media showed that only a few senior citizens showed up for Sinopharm jabs in Mandalay for the first three days. Later, it announced that it had administered the vaccines to school teachers and prisoners in Yangon and Naypyitaw. The regime said that it would prioritize the vaccine program for health workers and other essential staff, including those in the banking, wholesale and retail sectors.

News (17)

Yangon residents skeptical of CCP virus vaccines, reject the military regime, reject CCP

Many residents in Yangon are skeptical of CCP's covi vaccines and refuse the jab to defy military rule. A resident of Thaketa Township in Yangon, a neighborhood badly hit by the virus, told The Irrawaddy that “at least one or two people from every household in my ward are infected with COVID-19. It is too late for those people to get the vaccine”.

“Personally, I won’t take the Chinese shot because China (CCP) supports the regime. By offering the vaccine, they are helping to make the junta legitimate. I do not believe them,” he added.

Dr. Thuzar Aung, a medic participating in the civil disobedience movement, suggested that everyone should take the vaccine, but she also said that the regime’s vaccine rollout will not help to curb the spread of COVID-19.

News (18)

If there was no coup, Myanmar's vaccination plan would have been successful

“The efficiency of Chinese shots against the Delta variant is highly questionable. If there was no coup, our vaccination program might have been successful. Thousands of people who have died might not have done so. And we wouldn’t have to rely on vaccines made by the country that supports the junta,” she said.

“Now people are simply refusing to take the jabs because they don’t trust the regime,” she said.

The ousted National League for Democracy (NLD) government relied on Covishield, produced by the Serum Institute of India, which has demonstrated 95% efficacy against Covid-19. Last December, the NLD agreed to buy 30 million doses from India as part of an ambitious program to control the spread of coronavirus. It received the first 1.5 million doses from India as a gift in January.

The NLD also submitted a request to join the COVAX program run by the WHO and the Global Alliance for Vaccines and Immunisation, which aims to provide millions of doses to the most vulnerable people in 92 poor and middle-income countries.

Under the civilian NLD government, the plan was to have vaccinated 40 percent of Myanmar’s population by the end of 2021, with 20 percent of the vaccines provided by the COVAX program and 20 percent from vaccines bought by the government and approved by the WHO and the US Food and Drug Administration. Those plans were ended by the coup.

News (19)

200,000 doses of Sinopharm went to the Myanmar military

Now, the MOHS has said that it has only received 3.5 million Covishield vaccines from India. Besides, of the 500,000 Sinopharm vaccines donated by China in May, 200,000 doses have gone to the Myanmar military.

As of 18 July, more than 1.6 million people had been vaccinated, according to health minister Dr. Thet Khaing Win. That accounts for just over two and half percent of the population. Nor have the five and half million vaccines from COVAX which were supposed to be sent in March arrived. They have reportedly been delayed after the junta failed to provide details of its planned vaccine rollout.

Despite that, Dr Thet Khaing Win said that 50 to 55 percent of the country’s population is expected to be vaccinated by the end of the year. Regime-controlled newspapers continue to urge people to use whatever vaccines the junta offers them.

News (20)

Every covid death in Myanmar is caused by the Myanmar Junta

A business man in Yangon’s Botahtaung Township told The Irrawaddy, “I count every death of COVID-19 as someone who was killed by the regime. Without the coup, we wouldn’t be facing this situation. People have already sacrificed a lot in the fight against military rule,’ he said.

“I know that we are facing a deadly virus,” he added. “But I don’t want to kneel down to the junta for the vaccine. I will never do that. But, more importantly, I do not trust either the junta or the China (CCP) vaccine.”



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