AZ, Moderna, and Comirnaty are all in place. Comparison of the advantages and disadvantages of the 3 major vaccines
AZ vaccines donated to Taiwan by Japan continue to arrive, and Moderna vaccines purchased by Taiwan and the United States have also arrived in Taiwan, and Pfizer-BioNTech vaccines/Comirnaty purchased by Hon Hai, Taiwan-based TSMC, and Tzu Chi Foundation will arrive after September 2021. Therefore three major brands of covi vaccines are available to Taiwanese people. How to choose vaccines?
Experts say that a vaccine is a good vaccine, but people with autoimmune diseases in an active period should not be given an adenovirus vector vaccine. In an emergency, AZ is the best choice.
From now on, people over 18 years old across Taiwan can register their willingness to register for vaccines. How to choose a vaccine?
Xie Mingjia, a physician in the Department of Endocrinology and Metabolism, said that many people are now rushing to fight for the Moderna vaccine, and some people have indicated that they are willing to wait for Comirnaty. The main reason is that everyone is worried that the AZ vaccine is prone to thrombosis and the protection is only 70% to 80%. They also believe that the mRNA vaccine technology. In research, it has been pointed out that its protective power is as high as 94% to 95%. So everyone rushes to fight. But in fact, the protective power of these three vaccines are carried out independently in different environments, with different temporal and spatial backgrounds, and the race and age of the vaccinators.
So far, no one has put the three vaccines together for modification.
News (14)
Notarized evaluation: Is the 70% or 80% protective effect of AZ less effective than the 94% and 95% of the mRNA vaccine?
Is the side effect of AZ relatively high? Actually, it is different from what you think. Taiwanese people are rushing to fight for the Moderna vaccine, mainly because they are worried that the AZ vaccine will have high side effects and high adverse reactions. But in fact, the current data show that the side effects of the AZ vaccine may be the smallest of the three vaccines. Except for the fever rate, the AZ vaccine has 40 to 50% of the first dose, which is higher than 3% to 10% of the two mRNAs, and has the lowest side effects such as pain at the site of administration and muscle pain.
Xie Mingjia said that the AZ vaccine can be said to be a "bitter and sweeter" type of vaccine. Its first dose has large side effects, but the second dose has few side effects. However, Moderna and BNT vaccines have lower side effects in the first dose, and much more side effects in the second dose. This is why they have recently faced various variant viruses. The medical community believes that after two doses of the complete vaccine, three doses may be needed to reinforce it. However, the EU has doubts because the side effects of the third dose of the mRNA vaccine will be more serious.
News (15)
Is there a risk of death from vaccination?
When Taiwan’s epidemic was at its worst, the mortality rate reached over 4%, the highest in the world. As more than 90% of the dead were found to be between the ages of 6 and 70, experts at the time called for the protection of Taiwan’s elders.
Originally, Taiwan’s elders were willing to vaccinate. Every day, there are reports of elders dying after vaccination, making everyone deterred from administering AZ vaccine to the elderly.
Medical consultation expert and physician Xie Mingjia said that Europe and the United States have received more covi vaccines than Taiwan, and there have been reports of people dying after vaccination. The AZ vaccine is the most popular in Europe, followed by the BNT vaccine, and the Moderna vaccine is the least.
However, according to the statistics of the adverse drug reaction database (EudraVigilance) collected from 27 European countries, the death reaction report, the AZ vaccine has 3,364 cases, Moderna has 4,147 cases, BNT vaccine has 7,420 cases, and AZ vaccine has the least.
In the death report after 3 vaccines, the AZ vaccine death rate was 1.15%, which was several times lower than Moderna’s 8.41% and BNT’s 3.11%. Xie Mingjia said that so far, no matter whether it is in Europe or the United States, it has not been confirmed that any deaths are directly related to the vaccination.
On 13 July, the Central Epidemic Command Centre issued an anatomical case report on "Death after Vaccination". A total of 87 cases have been dissected, including 63 cases related to chronic diseases, 5 cases of choking, 2 cases of cervical spine fractures, 1 case of respiratory obstruction, 6 cases of suspected pneumonia, 2 cases of urinary tract infection, 1 case of tracheal perfusion fluid, 1 case of pharyngitis, 1 case of gastric perforation with peritonitis, 1 case of upper gastrointestinal bleeding, 1 case of pleurisy, 1 case was suspected of purulent infection of the biliary tract, and 2 cases need to be clarified, showing no direct relationship with the vaccine.
News (16)
The three vaccines have rare side effects
Because the three vaccines are made in different ways, the AZ vaccine puts a piece of DNA that makes the thorny protein on the surface of the virus into a sterilized adenovirus, and sends it into human cells through the vaccine to induce an immune response. Moderna and BNT vaccines are message RNA vaccines. The vaccine sends the mRNA that can produce the spike protein on the surface of the novel coronavirus to human cells and produces spike proteins, thereby driving the immune system to attack and remember such viral proteins, and produce immunity of the novel coronavirus, due to different production methods, has also been observed with different rare side effects.
The rare side effect of the AZ vaccine is thrombosis and thrombocytopenia. It usually occurs in young women. There are reports that young means under 40 years old, or under 50 years old. The incidence rate is 3 to 10 parts per million. But over 65 years old, there is almost no risk of blood clots.
With the increase in the number of young people vaccinated with the Moderna and BNT vaccines, it has also been observed that the risk of myocarditis and pericarditis in the young population is higher.
Generally speaking, it is most common in men under the age of 30. There are also a small number of cases in young women, but the incidence is only about 12 per million, and there has been no death case so far.
Therefore, even if there is a risk, countries in the world still do not recommend that young people do not get vaccination. The three vaccines have enough protection for Moderna and the Phase 3 clinical trial report of the BNT vaccine showed that the protection is as high as 95%.
According to statistics from Israel, which has the highest vaccination coverage in the world, 600,000 people are vaccinated with the BNT vaccine. The protection against infection reached 92%, the protection against hospitalization reached 87%, and the protection against severe illness reached 92%. The performance was indeed very good. Although the Phase 3 clinical trial of the AZ vaccine shows that the infection protection is only 70%, which is not as good as the two mRNA vaccines, statistics conducted in the United Kingdom, which has the most AZ vaccines, show that the AZ vaccine has more than 90% protection against severe illness and can reduce it. There is also an 80% hospitalization rate among the elderly over 80 years old, and the protection effect is not inferior.
News (17)
AZ vaccine the first choice for elderly with severe illnesses and people with poor immunity
In 12 days, 70% of the protection is available. AZ is the first choice when the epidemic is severe. When the epidemic in Taiwan is severe, the government urgently arranges for the elderly to receive AZ vaccine. Xie Mingjia said that this is the right choice. Because the AZ vaccine can produce 76% protection from the 12th to 24th day after a dose of 1 dose, while 1 dose of mRNA vaccine is only 52%, it must be filled with two complete doses to provide complete protection. The interval between the two doses takes at least 8 to 12 weeks (recent studies have suggested that the protection effect is better every 16 weeks), so when the epidemic is severe, the first choice for the elderly and people with poor immunity should be the AZ vaccine.
News (18)
Pregnant women and people with weak health should choose Moderna
Pregnant women and those who are physically weak should choose mRNA vaccines. Because there has been a large-scale study of pregnant women’s vaccines in the United States, pregnant women who have received the Moderna vaccine have no serious adverse reactions. Therefore, pregnant women and people with relatively weak health are currently recommended and prefer to use Moderna.
However, it should be noted that the mRNA vaccine has to complete two doses of the complete vaccine before it has complete protection. Therefore, if the epidemic is not so severe, the elderly who do not want to receive the AZ vaccine can wait for Moderna or Comirnaty.
Adenovirus vector vaccines should not be used in severely active stages of autoimmune diseases. Although adenovirus vector vaccines are inactivated and adenovirus vectors are not toxic, if you are in patients with autoimmune diseases such as lupus erythematosus, the risk is high.
The dose of immune suppressing drugs, non-toxic adenovirus may have the risk of causing symptoms of infection. Xie Mingjia said that this situation has not really happened. It is a risk that scientists anticipated.
Therefore, it is recommended that such patients do not choose AZ or Janssen two adenovirus vector vaccines.
News (19)
A vaccine is a good vaccine
Xie Mingjia said that according to reports from various countries, the three vaccines have high protection. No one is worse than the other. So as long as there is a vaccine, it is a good vaccine. There is a chance to get a vaccine. Just go to the queue.
However, if young women are given the AZ vaccine and have symptoms of leg pain, soreness, and numbness, they should seek medical attention as soon as possible to prevent the side effects of thrombosis. If young men get the mRNA vaccine and develop symptoms such as wheezing and chest pain, they should seek medical treatment immediately to prevent myocarditis and pericarditis.
News (20) to (22) / Editor : Liu Lijun
News (20)
Post-epidemic layout! Pharmaceutical factory develops covi oral drug in Taiwan where one of the Phase III clinical trials will be carried out
The pharmaceutical company develops the covi oral drug. Taiwan has become a clinical trial country to fight SARS-CoV-2. In addition to fighting for the coverage of the vaccine, Taiwan must also match vaccines with therapeutic drugs.
The international pharmaceutical company Merck is developing oral drugs and is currently undergoing Phase III clinical trials worldwide. Asia Regions including Taiwan, Japan, and the Philippines have all become test sites. Not only does it represent that Taiwan's medical strength has been internationally recognized, but it will also have the opportunity to buy oral medicines for the treatment of SARS-CoV-2 in the future after covid becomes flu.
To prevent SARS-CoV-2 from spreading, the global vaccine coverage rate must quickly reach herd immunity. One shot is injected into the body, and the heart is at peace. Now, in addition to pre-prevention, there are also oral new drugs. International company Merck & Co., Ltd. is developing anti-covi drug.
Reporter Liu Lijun said, "This covi oral drug is mainly used for (treatment), mild and moderate patients with a treatment period of 5 days. The third phase of clinical trials is currently being conducted in the world, and Taiwan is also one of them. The National Taiwan University Hospital and the Ministry of State-owned Taoyuan Hospital, as the test sites, began to receive documents in early July. The results of the global test are expected to be released in autumn, and mass production will be available at the end of the year at the earliest."
News (21)
Merck's third global launch of clinical trial involving 1,850 people
Phased clinical trials in Asia are being conducted in Japan, the Philippines and Taiwan. This hard-won opportunity will be hosted by Zhang Shangchun, the expert advisory group, and will work together with the commander Chen Shizhong and Wang Bisheng, the CEO of the Medical Welfare Association.
Commander Chen Shizhong on 10 July said, "Everyone's assessment thinks that it has, its value and its convenience, because it is an oral solution, and it has a certain effect in the early stage for preventing it from becoming severe. Experiment, but it is very attractive to us because it is oral.”
Expert advisory group convener Zhang Shangchun said, “When we participated in global clinical trials, we also did quite well, so in this time, in the case of a case, I feel that the new drugs in clinical trials are going to Taiwan and the world will be carried out together. These are the patients who are mild to moderate and non-hospitalized. For patients, the mode of treatment must be matched with the way the entire country accepts patients.”
According to the second phase clinical trial report released by Merck in early March, five days after the administration of the drug to the confirmed patient, it can significantly reduce the body of the patient.
Research shows that the new drug can effectively inhibit the RNA replication of a variety of viruses, and it has an effect on multiple new coronaviruses.
Lin Weiwen, the chief physician of the Department of Cardiology at Taian, said, "The virus will replicate in a large amount in the initial stage. After it invades our host cells, after a large amount of replication, many cells will be infected. At the initial stage, if the virus is inhibited from a large number of replication, it can effectively reduce the amount of virus. Once the amount of virus drops, our CT value will rise. Even if he has the virus on his body but his virus amount is not enough, he will not infect others, and he will recover faster.
Zhang Shangchun, convener of the TVBS expert advisory group, said, "Like flu oral medicine, after the initial diagnosis of symptoms, we start taking the medicine as soon as possible, and the chance of them becoming severely ill will be reduced."
News (22)
Taiwan hopes to procure covi oral drug through clinical trial
In the past, Taiwan lacked medicine. The experience of the third phase of clinical trials can now not only take the lead in future procurement, and deploy ahead of schedule for the next stage of flu-turning covid, but also inject more practical experience for Taiwan's biotechnology and medical industry.
Lin Weiwen, chief physician of Cardiology Department at Taian, said, "If we join the so-called Phase III clinical trial of the drug, we can basically exchange a lot of information with the original developer, and even some technical aspects. We can probably get a preliminary idea. For a brief understanding, for our future biotechnology industry, when we want to develop vaccines or drugs, we have a lot of experience to refer to when we are going to do the third phase in China. Assuming that the drug is successfully developed or it is on the market, we can get it. After the US EUA (Emergency Authorization), it can give priority to these countries for Phase III."
Taiwan’s experience in participating in Phase III clinical trials is very rare and the medical community is also very optimistic. Despite the gradual control of the domestic epidemic, it must not be slackened. It is still necessary to actively deploy to combat the re-invasion of the virus.
News (22)
CCP profited from selling vaccines to COVAX, US officials: Shock!
The head of the Biden Administration's Agency for International Development (USAID) stated that the CCP chose to sell vaccines to the "Covid-19 Vaccine Acquisition Mechanism" (COVAX) for profit, rather than donating or providing financial assistance. This is terrible and shocking.
The Voice of America reported that Samantha Power, Director of the Agency for International Development, attended the Senate Foreign Relations Committee's 2022 budget hearing held by the Senate Foreign Relations Committee on Wednesday (14 July) morning. During the period, she made the above statement.
Earlier this week, the Global Alliance for Vaccines and Immunization (GAVI) announced that it has signed purchase agreements with China National Pharmaceutical Group and Sinovac. The vaccines produced by these two companies will be included in the "New Coronary Vaccine Access Mechanism" (COVAX) vaccine library. It will start this month at the earliest.
The chief Republican member of the Senate Foreign Relations Committee and Senator Jim Risch of Idaho stated at a hearing on Wednesday that he was quite surprised by the decision to "buy" the Chinese vaccine when he saw the news a few days ago. And puzzled.
"Are they (COVAX) aware of the irony? This (epidemic) started in China, and then they refused to participate in COVAX, unwilling to provide financial aid, unwilling to provide vaccines, and then COVAX turned around and said they would pay Money to buy their vaccines." Senator Risch said, "I mean, it's weird, to say the least, it's weird."
Bauer said that she and COVAX have already discussed this. She couldn't believe this "purchase transaction".
"First, it is shocking that Beijing chose to profit from these vaccines instead of providing financial assistance to COVAX or donating the vaccines they have to COVAX to help people when they are in desperate need." Bauer said The hearing said: "There is no other statement, this is too shocking."
News (23)
Bauer: The CCP's actions are unobstructed
Just as China's Sinopharm vaccine and Sinovac vaccine CoronaVac were incorporated into COVAX, the question of the effectiveness of China's vaccine was growing. Senator Risch also asked questions about how countries view the effectiveness of vaccines from CCP China.
He said, "In the United States, we see that even minor effects will be really questioned. From what we know about the situation of Chinese vaccines, compared with the vaccines we produce, their quality seems to be quite poor."
Bauer's answer points to a major embarrassment faced by many countries that urgently need vaccines to control the epidemic: whether they accept Chinese vaccines, or do they have no vaccines at all.
"The problem now is not that COVAX chooses between Sinopharm, CoronaVac and Moderna. If that is the case, the choice is obvious. The problem now is to choose between a Chinese vaccine or no vaccine." Bao Er said.
She pointed out that countries obviously prefer vaccines made in the United States, especially those that use mRNA technology such as Modena and Pfizer. "Once the (US vaccine) supply problem is resolved, I think it will be an obvious choice." Bauer said.
Bauer went on to emphasize that in such a situation where global vaccine supply and demand are completely out of balance, "China (the CCP) has no excuses for what it is doing."
"We are very aware of what China (the CCP) is using its vaccines and people's despair in exchange for something. We (donations) do not require anything in return, unlike China (the CCP)." Bauer said.
News (24)
The United States is the world’s largest vaccine donor
The Biden administration announced the outline of its global vaccine sharing plan on 21 June. The goal is to distribute vaccines to countries in Latin America, the Caribbean, Asia and Africa where the epidemic continues to worsen. The White House stated that most vaccines donated by the United States are shared through COVAX. President Biden promised to share 80 million US-made vaccines with countries around the world.
President Biden also announced in early June that the United States would purchase 500 million doses of vaccine from pharmaceutical manufacturer Pfizer to donate to countries in need, also mainly through COVAX, of which 200 million doses of vaccine are expected to be sent out this year, and another 300 million doses. Will be issued in the first half of next year.
The White House stated in a written statement on June 21 that the United States "will not use vaccines to obtain benefits from other countries." The goals of the U.S. Vaccine Donation Program include increasing the global coverage of the new coronavirus (CCV) vaccination, preparing for a surge in cases, and helping "our neighbors and other countries in need."
The Biden administration sent three million doses of Moderna vaccine to Indonesia, which is deeply affected by the epidemic, last Friday. White House Press Secretary Jen Psaki said at the press conference, “In addition to delivering vaccines, we are also implementing plans to increase assistance for Indonesia’s overall response to COVID-19.”
The United States is currently the world's largest vaccine donor. The member states of the Group of Seven, composed of wealthy countries, have pledged to provide 1 billion doses of vaccine globally, of which approximately 580 million doses come from the United States.
Bauer said on Wednesday that although US vaccines are sent to countries through COVAX, the US flag will be affixed to the sealed box. "When our higher-quality vaccines arrive in various countries, we will let everyone know." She said.
News (25) to (27) / Reporter : Li Xi / Editor : Lin Congwen
News (25)
"The CCP's Internet Stability Maintenance Training Course" was exposed, netizens found Communist supporters
Wang Jing, a citizen reporter of Tiananwang.com, who was exiled overseas, has recently been subjected to various harassment due to a statement of "overthrowing the tyranny of the CCP". Recently, she discussed this topic several times with netizens on the Telegram group of the social media "constitutional democracy", and compared with the content of the "CCP Network Stability Maintenance Training Course", she and other netizens thought that these people were Communist supporters or wumao.
News (26)
Network navy penetrates domestic and foreign communities
Wang Jing told the Epoch Times reporter, "On the night of the 14th, a few informants and I unearthed a fifty cents named ‘constitutional democracy’ in Telegram’s ‘Universal Values-Free Group’ group."
"Five-mao’s point of view is: China’s realization of democracy must not rely on violence to seize power. It must use hunger strikes and popularize democratic non-violent ideas among the people. If 100 hunger strikes fail, then 101 hunger strikes. One day it will succeed, but it just cannot. Violent seizure of power, as long as the violent seizure of power must be the next dictator." She said.
Wang Jing and netizens debated on "constitutional democracy": "Don’t you see how great the threat the CCP poses to mankind? How many people have been killed by the CCP? There are so many political prisoners and prisoners of conscience in Chinese prisons. How do people in fear hope to be rescued as soon as possible? At present, anti-Communist is the prerequisite for realizing Chinese democracy. Moreover, when we talk about overthrowing the CCP, we don’t say that we must be violent or kill all the bad guys."
Netizens "constitutional democracy" said: "Will robbers arise for no reason? Want to know why robbers are produced? Will there be flies without dung?" Wang Jing said, "This sentence fully exposes the anti-human thinking of fifty cents. ."
Wang Jing responded, "This sentence of yours reveals your true position. You are speaking for the CCP. You think that the quality of Chinese people is poor. It is not because of the CCP's cruelty and evil that the Chinese people still live. In the hell on earth; you think that Chinese people are of poor quality, that's why the CCP treats them like ants."
At this time, a netizen sent a picture of the "Network Stability Control Training Course for the CCP Authorities". In comparison with the content, Wang Jing basically understood and determined that the CCP not only controls all domestic and foreign media, but also those at home and abroad. This chat tool group is also mixed with the CCP’s cyber navy.
Wang Jing believes, “They often reverse right and wrong, misleading public opinion, and wrongly leading the rights protection thinking and direction of China’s victimized victims. The CCP’s only purpose in doing this is to paralyze the masses and prolong their lives.”
News (27)
The Chinese Communist Party poison Chinese people
Recently, Mr. Qi of Shanghai and an old friend often argued about the truth of the "pseudo-fire" self-immolation case. Mr. Seven revealed to the Epoch Times reporter, "I am clarifying the truth with him at the risk of being reported. I hope he can restore his normal conscience and be a dignified Chinese."
(Editor’s note: On January 23, 2001, the “Tiananmen self-immolation case” that shocked the world took place on Tiananmen Square in Beijing. The CCP lied that five self-immolators were Falun Gong practitioners. The Chinese were brainwashed. However, due to the many flaws in this pseudo-case, it has been exposed as a self-defeating “false fire” by various parties at home and abroad for two decades. On August 14 of that year, the International Education Development Organization met at the United Nations. On the previous page, regarding the Tiananmen Square self-immolation incident, it strongly condemned the CCP’s “national terrorism” behavior. The statement said: According to the video analysis, the entire incident was “directed by the government.” The CCP delegation faced conclusive evidence and did not argue. The statement has been filed by the United Nations.)
Mr. Qi told this friend, “People in their sixties don’t know what is right or wrong. You still need your'party mother' to check for you at all times to 'discriminate right from wrong' and screen what you can see and what you can't. You are also proud of the sources of information that can be cut off to the end. You can’t do that."
"In the original footage of CCTV (CCTV), hundreds of millions of people saw Liu Chunling (one of the figures in the self-immolation case) die on the spot. This is a matter announced by CCTV. Those who understand some forensic knowledge, unless there is sufficient logical explanation , Will tend to judge on-site homicide. At this stage, all you admire are only one family, and there is no evidence at all. And what you admire has long been proved to be nonsense by the massive evidence from all parties."
Mr. Seven said, “The demons (friends) admire will only take care of themselves and take blood from billions of people. They don’t want to bear any responsibilities, an excuse against humanity.”
News (28) to (30) / Report by : Gan Yung Chyan, KUCINTA SETIA
News (28)
Sellin: The vast majority oppose Miles Guo
According to the recent Twitter posts, Lawrence Sellin, AstraZeneca pharmaceutical expert and former U.S. Army colonel, revealed that the vast majority oppose Miles Guo as he now sides with the CCP. The reason why he has changed his stand and now sides with the CCP although he has ensured Yan Limeng's safe arrival in the U.S. from Hong Kong, with Steve Bannon, is unknown.
Sellin tweeted, "The vast majority oppose CCP agent Miles Guo Wengui". He later tweeted that Guo has been recruiting so-called "asylum-seekers", that are actually "young CCP agents and provocateurs" "to conduct operations against anti-CCP dissidents in the U.S."
Miles Guo founded the New Federal States of China in the U.S. to challenge the CCP in 2020. He is the person to reveal that SARS-CoV-2 is a bioweapon developed in the communist land to fight against the Democracy supporters in Hong Kong in an interview with the Vision Times in early 2020.
News (29)
Agents and provocateurs of Miles Guo hunting for Yan Limeng
Sellin mentioned that Yan Limeng is in great danger because of these agents and provocateurs of Miles Guo.
Sellin revealed that Limeng has made contact with Trump's inner circle to seek protection. He has remarked, "CCP agent Miles Guo Wengui should be more careful who he threatens on his videos or to whom he send his cult members to harrass. Those cult members are being photographed and identified for the police."
News (30)
CCP agents and provocateurs in the U.S. should be arrested
One hour ago, Sellin tweeted the message below.
News (31) to (35) / Publisher : The Irrawaddy
News (31)
Myanmar descends into country failure
News (32)
Myanmar Junta putting lives of political prisoners at risk in covid prison outbreaks
News (33)
Myanmar announces nationwide lockdown from 19 July 2021
News (34)
Myanmar's shortage of medical oxygen is the biggest killer
News (35)
Banning the NLD will not end resistance against Myanmar Junta
No comments:
Post a Comment