"Antibody cocktail therapy" works on Trump
Reporter : Luo Tingting / Editor: Wang Anping / https://www.ntdtv.com/gb/2020/10/04/a102955769.html / Extract translation, editing : Gan Yung Chyan, KUCINTA SETIA
US President Trump has been diagnosed for three days. White House doctor Sean Conley said in the morning of 3 October at the Walter Reed National Military Medical Center that Trump is currently in good condition and some of his previous mild symptoms have already reduced. He has started to get better. Conley said earlier that Trump had received "multi-strain antibody cocktail therapy" as a "preventive measure."
Conley said that Trump "is very well this morning." He has not had a fever for more than 24 hours. His previous mild cough, nasal congestion and fatigue have all improved. "We are very happy with his progress."
Conley announced to the outside world on 2 October that Trump had injected a dose of "multi-strain antibody cocktail therapy" from Regeneron Pharmaceuticals of the United States after his diagnosis. As a "preventive measure", no adverse reactions occurred.
According to a press release issued by Regeneron Pharmaceuticals on September 29, this "REGN-COV2" antibody cocktail therapy is a combination of two monoclonal antibodies. The antibodies work by binding to the virus to prevent it from entering the cell and multiplying. In the early stage of infection, it can effectively reduce the amount of virus in the patient's body and improve symptoms.
The company's president and chief scientific officer, Dr. George D. Yancopoulos, said in a statement that the newly developed "REGN-COV2" rapidly reduced the viral load and related symptoms of patients infected with SARS-CoV-2 (CCP virus). After injection for mild or asymptomatic patients, the effect is more obvious, and the symptoms can be relieved in 6 to 8 days, which is much less than the traditional 13 days.
According to the report, Leonard S. Schleifer, CEO of Regeneron Pharmaceuticals, has been in personal relationship with Trump for many years and is also a member of Trump Golf Club. Shriver said that Trump's medical team took the initiative to contact medication matters, "we are very happy."
Due to the limited supply of the drug, Regeneron Pharmaceuticals plans to increase production to meet the subsequent demand.
In addition, Trump moved into Walter on the afternoon of the 2nd. After the Reed National Military Medical Center, it used the experimental antiviral drug "Remdesivir" developed by the American biopharmaceutical "Gilead Sciences".
Remdesivir has a moderate effect on patients infected with the CCP virus. In May of this year, the U.S. Food and Drug Administration (FDA) has urgently authorized remdesivir to become a therapeutic drug for covid treatment.
Conley said that President Trump has taken the first dose of remdesivir and has a good rest. At the same time, Trump also takes drugs such as zinc, vitamin D and aspirin that help strengthen the immune system.
According to media reports, the Reed National Military Medical Center has 6 special wards dedicated to cabinet-level officials. Trump stayed in the presidential suite "Ward 71". The suites are luxuriously furnished, including a living room, bedroom, doctor's office, and meeting room. As with restaurants, Trump can work directly in the room.
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News (2)
What is the principle of Trump’s treatment of "antibody cocktail therapy"?
Reporter : Tan Jingjng / Publisher : XinhuaNet via ScienceNet / http://news.sciencenet.cn/htmlnews/2020/10/446528.shtm / Translation, editing : Gan Yung Chyan, KUCINTA SETIA
US President Trump said on social media in the early morning of 2 October that he and his wife Melania had tested positive for SARS-CoV-2 (covi, in short, CCP virus). Later that day, White House doctor Sean Conley said that Trump received "antibody cocktail therapy."
Conley said in a statement that after Trump was diagnosed positive, as a preventive measure, Trump received polyclonal antibody treatment from Regeneron Pharmaceuticals, a single dose of 8 grams. In addition, he also takes zinc, vitamin D, famotidine, melatonin and aspirin.
What is the principle of this antibody cocktail therapy? How's the effect?
According to the official website of Regeneron Pharmaceuticals, this therapy called REGN-COV2 is composed of two monoclonal antibodies REGN10933 and REGN10987, which are designed to block the process of covi infecting the human body. These two antibodies bind to the key receptor of the covi spike protein in a non-competitive manner. The combination of the two can reduce the ability of the mutant virus to evade single antibody treatment.
On 29 September, Regeneron Pharmaceuticals announced the early results of clinical trials of the therapy. The results show that this therapy reduces the viral load and shortens the time it takes for non-hospital patients with covid to relieve symptoms. For patients who have not produced an effective immune response to covi, the effect of this therapy is most obvious.
Regeneron Pharmaceuticals initially recruited 275 non-hospital covid patients to participate in the trial. These patients were randomly divided into 3 groups and received a single intravenous injection of 8 grams (high dose) of antibody cocktail therapy, a single intravenous injection of 2.4 grams (low dose) of the therapy, and a placebo. Before treatment, the researchers performed relevant serum tests on the patients to determine whether they had produced antibodies themselves.
The test results showed that the median time to symptom relief for seronegative patients who received placebo was 13 days, for patients who received high-dose therapy for 8 days, and for patients who received low-dose therapy for 6 days. Both doses of antibody cocktail therapy were well tolerated.
Regeneron Pharmaceuticals said that in addition to clinical trials on non-inpatient patients with covi, its researchers are studying the effects of antibody cocktail therapy in hospitalized patients.
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