Reporter : Zhang Qingdan / Publisher : China Science News
Ref : http://news.sciencenet.cn/htmlnews/2020/8/444308.shtm / Direct translation
Recently, the proteomics team of the Institute of Bee Research of the Chinese Academy of Agricultural Sciences (hereinafter referred to as the Institute of Bee Research) discovered that the unique unsaturated fatty acid 10-hydroxy-2-decenoic acid (10-HDA) in royal jelly has the function of protecting immune organs and promoting Immune potential. Relevant research results were published in "Targeted Therapy Expert Opinion".
According to Professor Li Jianke of the Institute of Honeybees, the human immune mechanism can be divided into innate immunity and acquired immunity, including cellular immune responses mediated by T lymphocytes (T cells), that is, T cells specifically recognize and kill virus infection or tumor cells, and The humoral immune response mediated by B lymphocytes (B cells) means that B cells secrete specific antibodies to eliminate harmful antigens that enter the body. The immune organs thymus and spleen are the places where T cells and B cells mature. Royal jelly is a traditional health food, among which 10-HDA is only found in royal jelly, also called "Royal Jelly Acid". It has biological activities such as antibacterial, anti-inflammatory, anti-tumor, blood-brain barrier protection and skin damage. The immune mechanism is not clear.
Cyclophosphamide is a commonly used drug for preparing animal models with low immunity. After intraperitoneal injection of cyclophosphamide into experimental mice, the thymus coefficient and spleen coefficient of the mice decreased significantly. On this basis, the thymus coefficient and spleen coefficient of the mice could be significantly restored by intragastric administration of 10-HDA, indicating that 10-HDA can slow down the damage of thymus and spleen caused by cyclophosphamide. The team's research found that 10-HDA can restore the expression of T cell/B cell proliferation, T cell killing ability, B cell antibody affinity maturation, and antigen presentation that are inhibited by cyclophosphamide in the thymus and spleen, thereby achieving Protect immune organs and restore suppressed immune function.
The research was funded by the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences, the Bee Industry Technology System, the National Bee Industry Quality Improvement Project, and the Open Fund of the Key Laboratory of Pollination Insect Biology of the Ministry of Agriculture and Rural Affairs.
Related paper information: https://doi.org/10.1080/14728222.2020.1733529
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