Reporters : Sun Guoyin, Huang Xing
Publisher : China Science Daily, via ScienceNet
Translation, editing : Gan Yung Chyan
/ KUCINTA SETIA
Image courtesy : Unsplash
Yu Jintai, professor of neurology at Huashan Hospital Affiliated to Fudan University, and the clinical research team of Professor Tan Lan of the Department of Neurology of Qingdao University, in a large clinical cohort study of nearly 1,000 people, found that frequent sleepiness during the day, insufficient sleep at night, or excessive sleep can increase recognition. Knowing the risk of cognitive impairment, sleeping 6-7 hours a night can reduce the risk of cognitive impairment. Related research results were recently published in the "Journal of Alzheimer's Disease and Dementia".
In this study, the researchers first established a large-scale cognitive impairment clinical research database and biological sample bank, based on the established CABLE cohort (Chinese Alzheimer's Disease Biomarker and Lifestyle Research). The effects of various sleep characteristics on the pathophysiological changes of Alzheimer's disease (the most common type of dementia) were discussed.
For the first time, researchers have confirmed the U-shaped relationship between sleep time at night and the pathogenesis of Alzheimer's disease in the middle-aged and elderly people from the level of biomarkers: that is, insufficient or excessive sleep can promote abnormal amyloid deposition in the body.
Amyloid deposition is a common pathway that induces Alzheimer's disease and a key factor in the formation and development of the disease. It is also one of the core pathological features of Alzheimer's disease. Dysfunction during the day (such as frequent sleepiness during the day) can also promote abnormal deposition of amyloid in the body.
The best sleep mode is to fall asleep at 10 o'clock every night and sleep for 6-7 hours. Under this sleep mode, the abnormal deposition level of amyloid in the brain is the lowest.
At the same time, the researchers also used evidence-based medicine to map the evidence system of the association between sleep and cognitive impairment (including Alzheimer’s disease) risk, and found that 10 sleep characteristics (disorders) can promote the occurrence of cognitive impairment. Six of them are supported by moderately strong evidence, including insomnia, split sleep, day dysfunction, prolonged incubation period, rapid eye movement sleep behavior disorder, and excessive bedtime. Further dose-response analysis found that there is a U-shaped relationship between sleep time at night and the risk of Alzheimer's disease: that is, the optimal night sleep duration may be between 5.6 and 7 hours. Sleeping at night for less than 4 hours or more than 10 hours, the risk of cognitive impairment will increase significantly.
"This study not only confirmed the U-shaped relationship between night sleep time and Alzheimer’s disease from the biomarker level for the first time, but also confirmed from the biological mechanism that sleep characteristics can increase Alzheimer’s by affecting the deposition of amyloid. The risk of disease.” Yu Jintai said that in order to prevent the occurrence of cognitive impairment and dementia, sleep management should be emphasized.
Related paper information: https://doi.org/10.1002/alz.12117
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