Reporter : Yu Ning
Editor : Chang Qing
Publisher : Sound Of Hope
Ref : https://www.soundofhope.org/post/381541
Translation, editing : Gan Yung Chyan
/ KUCINTA SETIA
Image courtesy : PhotoAC
The latest research found that SARS-CoV-2 (covi, in short) is very different from conventional viruses in that this virus can prevent human cells from interfering with their reproduction in the body, and to induce the body's immune system to fight excessively and cause self-injury. A researcher said that this is a virus he has rarely seen in more than 20 years of virus research.
According to the Daily Mail report, under normal circumstances, when the human body is infected with a virus similar to influenza virus or severe respiratory syndrome, human cells will release two genes, one is interferons (interferons) used to prevent the virus from multiplying in the human body. ), The other is the chemokines that stimulate the human immune system to eliminate invading viruses. However, a team from the Icahn School of Medicine at Mount Sinai in New York City found that, unlike other viruses, covi can block human infected cells. The ability to produce interferon, but it will not affect the production of chemokines by infected cells, which leads to the uncontrolled reproduction of the virus in the human body, and the chemokines triggered by the human body in response to the invading virus are triggered in the human body A cytokine storm can seriously damage human organs that have been severely damaged by the virus, causing severe systemic inflammation in many patients.
The team's paper published in the journal "Cell" stated that they discovered this situation by studying the cells of two patients who had died from covi. Benjiamin tenOever, a virus expert and professor of microbiology at Icahn School of Medicine, said that the human body has two genes that resist invading viruses, interferons and chemokines, of which interferons are released and interfered by infected cells The virus reproduces itself in the patient's body; the chemokine is a gene released by infected cells that activates the body's immune cells to eliminate the virus at the lesion; under normal circumstances, interferon will control the virus for the first 7 to 10 days and the chemokines eliminate these invading viruses at the same time.
He said, "In these two joint forces, most of the virus will be neutralized naturally and then cleared by the body's immune system. Sometimes it is just the first one, to prevent the virus from multiplying in the patient's body. It completely eliminates the virus invasion and neutralizes the invading toxin, so there is no need to initiate the second stage response. "But SARS-CoV-2 is different from the influenza virus and the severe respiratory syndrome virus, because it prevents the first stage response, However, the response of the second phase was strengthened, resulting in a small amount of interferon in the patient, but a large amount of chemokine. He said, "This is a very bad combination."
He explained that when a person is infected with covi, the virus enters the lungs. Because there is no interferon to contain it, the virus will multiply uncontrollably in the patient ’s lungs, causing the lesions to ulcer quickly; but this A larger number of infected cells activate chemokines, resulting in a large number of cells such as neutrophils, macrophages, and lymphocytes, which in turn cause disease The inflammation of the affected lungs and other organs is more serious, just like a cytokine storm, which eventually causes the body's own immune cells to damage its own cells and tissues, rather than eliminate the virus.
He also stated that he saw this phenomenon for the first time in his more than 20 years of virus research career.
He therefore suggested that doctors should try to restore the function of interferon sent by infected cells when they treat covid patients, and those patients who have been hospitalized for a while and have been intubated because of the serious condition should use drugs such as interleukin-6 or leukemia-1 help to slow down the cytokine storm that appears in patients, and at the same time reduce the symptoms of systemic vascular inflammation in patients.
Editor : Chang Qing
Publisher : Sound Of Hope
Ref : https://www.soundofhope.org/post/381541
Translation, editing : Gan Yung Chyan
/ KUCINTA SETIA
Image courtesy : PhotoAC
The latest research found that SARS-CoV-2 (covi, in short) is very different from conventional viruses in that this virus can prevent human cells from interfering with their reproduction in the body, and to induce the body's immune system to fight excessively and cause self-injury. A researcher said that this is a virus he has rarely seen in more than 20 years of virus research.
According to the Daily Mail report, under normal circumstances, when the human body is infected with a virus similar to influenza virus or severe respiratory syndrome, human cells will release two genes, one is interferons (interferons) used to prevent the virus from multiplying in the human body. ), The other is the chemokines that stimulate the human immune system to eliminate invading viruses. However, a team from the Icahn School of Medicine at Mount Sinai in New York City found that, unlike other viruses, covi can block human infected cells. The ability to produce interferon, but it will not affect the production of chemokines by infected cells, which leads to the uncontrolled reproduction of the virus in the human body, and the chemokines triggered by the human body in response to the invading virus are triggered in the human body A cytokine storm can seriously damage human organs that have been severely damaged by the virus, causing severe systemic inflammation in many patients.
The team's paper published in the journal "Cell" stated that they discovered this situation by studying the cells of two patients who had died from covi. Benjiamin tenOever, a virus expert and professor of microbiology at Icahn School of Medicine, said that the human body has two genes that resist invading viruses, interferons and chemokines, of which interferons are released and interfered by infected cells The virus reproduces itself in the patient's body; the chemokine is a gene released by infected cells that activates the body's immune cells to eliminate the virus at the lesion; under normal circumstances, interferon will control the virus for the first 7 to 10 days and the chemokines eliminate these invading viruses at the same time.
He said, "In these two joint forces, most of the virus will be neutralized naturally and then cleared by the body's immune system. Sometimes it is just the first one, to prevent the virus from multiplying in the patient's body. It completely eliminates the virus invasion and neutralizes the invading toxin, so there is no need to initiate the second stage response. "But SARS-CoV-2 is different from the influenza virus and the severe respiratory syndrome virus, because it prevents the first stage response, However, the response of the second phase was strengthened, resulting in a small amount of interferon in the patient, but a large amount of chemokine. He said, "This is a very bad combination."
He explained that when a person is infected with covi, the virus enters the lungs. Because there is no interferon to contain it, the virus will multiply uncontrollably in the patient ’s lungs, causing the lesions to ulcer quickly; but this A larger number of infected cells activate chemokines, resulting in a large number of cells such as neutrophils, macrophages, and lymphocytes, which in turn cause disease The inflammation of the affected lungs and other organs is more serious, just like a cytokine storm, which eventually causes the body's own immune cells to damage its own cells and tissues, rather than eliminate the virus.
He also stated that he saw this phenomenon for the first time in his more than 20 years of virus research career.
He therefore suggested that doctors should try to restore the function of interferon sent by infected cells when they treat covid patients, and those patients who have been hospitalized for a while and have been intubated because of the serious condition should use drugs such as interleukin-6 or leukemia-1 help to slow down the cytokine storm that appears in patients, and at the same time reduce the symptoms of systemic vascular inflammation in patients.
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