Sunday, March 29, 2020

Asymptomatic patients of COVID-19 are as equally infectious as symptomatic patients

Copywriter : Wu Yu, Chnfund.com
Extract translation, editing : Gan Yung Chyan
                                            / KUCINTA SETIA

Image : Zhang Wenhong (public domain). STCN

According to Zhang Wenhong, the Director of the Department of Infectious Diseases of Huashan Hospital affiliated to Shanghai Fudan University and senior expert group leader of the Shanghai expert treatment group of Novel Coronavirus Pneumonia [ Novel coronavirus, COVID-19 (covid, in short) ], the biggest current risk of the pandemic is asymptomatic infection. Such patients have strong immunity and can not get sick within 14 days after being infected with the virus. The virus has been in the body for more than three weeks and has the possibility of infection. If they are not detected and isolated in time, there is a hidden danger of community transmission.

According to a Harvard infectious disease expert study, 40% of COVID-19 patients are asymptomatic, and Zhang Wenhong also said that in more than 100 imported cases in Shanghai, more and more patients are found asymptomatic.

Zhang Wenhong: Asymptomatic infection can be infected for 14 days without the possibility of infection

In the afternoon of  27 March 2020, a seminar on "Basic Research and Prevention Practices on Virus Evolution, Evolution, and Transmission-From SARS to COVID-19" hosted by the Shanghai Municipal Science and Technology Association's Biomedical Professional Committee was held at the Shanghai Science Hall. Talking about the problem of asymptomatic infection, Zhang Wenhong,  said at the meeting that this is an important type of surveillance in the "second half" of epidemic prevention and control aims. Wu Fan, Deputy Dean of Shanghai Medical College of Fudan University and President of the Shanghai Preventive Medicine Association, pointed out that the most effective way to prevent infection by such people is to strengthen personal protection.

The full name of "asymptomatic infection" is "asymptomatic infection of novel coronavirus", which refers to those who have no clinical symptoms, but positive for the pathogenic test of novel coronavirus in respiratory specimens.

Zhang Wenhong introduced that the asymptomatic infected person has strong immune ability and cannot get sick within 14 days after infection with the virus. The virus has been in the body for more than three weeks and has the possibility of infection. If they are not detected and isolated in time, there is a hidden danger of community transmission.

In Zhang Wenhong's view, this is exactly the trickiness of the virus. "There are asymptomatic infections of the novel coronavirus virus. Such patients have no clinical symptoms, but the pathogenic test is positive, which brings challenges to epidemic prevention and control." So " It is necessary for Shanghai to implement the "100% Novel Coronavirus Nucleic Acid Test for Inbound Persons in Shanghai" to maximize the screening of asymptomatic infections from abroad.

"So far, I think this virus is one of the most difficult viruses in human history." Zhang Wenhong said.

Why are there asymptomatic people? Zhou Qi, an academician of the Chinese Academy of Sciences, explained in a recent interview with Bai Yansong/ "The novel coronavirus virus is cunning, disguising itself in the evolution of the virus and continuously spreading it. Some of the so-called asymptomatic infections may not have found more effective testing methods and testing reagents, and we may not find more important symptoms and signs of clinical testing that deserve attention."

The initial development of the virus is not so invasive, and its harm is reflected in the symptoms of its outbreak after the human body is latent. Therefore, in the future prevention and control process, how to prevent, warn, and detect earlier, and have some clear precautions, is the main research direction.

What if there are asymptomatic infections around us? Wu Fan, Deputy dean of Shanghai Medical College of Fudan University and president of the Shanghai Preventive Medicine Association, said that people's most effective means to strengthen personal protection is to wash their hands frequently and wear masks on some occasions.

Data show that there are four main ways to find asymptomatic infections:

The first is the active detection of close contacts of patients with new coronary pneumonia during medical observation;

The second is the active detection carried out in the investigation of cluster epidemics;

The third is the active detection of exposed populations during the tracking of the source of infection of covid cases.

The fourth is the active detection of travel history and residence history in some areas with new cases of continuous transmission of covid.


Asymptomatic infection in imported cases

Zhang Wenhong introduced that more and more asymptomatic patients are found in more than 100 imported cases in Shanghai. He said that “quick diagnosis is extremely important, otherwise it means that a large number of patients will stay in the community and cause community outbreaks. . "

There have been many cases of asymptomatic infections imported overseas. Fellaini, a foreign aid who previously played for Shandong Luneng Taishan Football Club, entered Shanghai and was diagnosed in Jinan. The club stated that his body temperature had been normal during the isolation period and there were no other discomforts. On March 27, Zhejiang Jiaxing informed a Beijing returning man that he had been diagnosed. An epidemiological investigation revealed that he had an asymptomatic infection imported from abroad on the same flight.

The Ministry of Foreign Affairs and the Immigration Administration of China issued an announcement on 26 March 2020, deciding to temporarily suspend entry of foreigners with currently valid visas and residence permits in China from 28 March 2020. Zhang Wenhong said that the greatest risk of imported epidemic risks is asymptomatic infection. "Now we only allow Chinese people to come back, but when our country's door opens again, there will be a large number of friends in the world. He is asymptomatic. So the risk is great.

On 27 March 2020, Beijing also reported that a case of asymptomatic infection was arrested on the grounds that it was suspected of obstructing the prevention of infectious diseases.

The asymptomatic infected person Chang, who concealed Wuhan's residence history and failed to implement home isolation measures, caused the mother's infection and more than 20 close contacts to be isolated.

According to an official report, Changmou drove out of the city to Changsha in the early hours of the city’s closure on 23 January 2020, and then flew to Beijing to enter the mountainous area of ​​his mother ’s house. He concealed his residence history during the epidemic and repeatedly entered supermarkets, drug stores and other public places. He was diagnosed with asymptomatic infection on 18 March. On 20 March 2020, Chang was criminally detained by public security bodies after being treated in isolation. On 26 March 2020, the Fangshan District People's Procuratorate of Beijing approved his arrest in accordance with law.

When Zhang Wenhong answered the question of epidemic prevention to international students and overseas Chinese on the 26th, he said that asymptomatic infection is not the mainstream of the infected people. So why does China attach great importance to this type of infection? He explained that China is currently in the "second half" of epidemic prevention and control, with few local cases, so more and more attention is paid to asymptomatic infection. Many European and American countries are in the "first half" of epidemic prevention and control, mainly dealing with symptomatic infection. This difference in degree of emphasis is determined by the different prevention and control stages.

Source : http://news.stcn.com/2020/0328/15776097.shtml
See also : Li Ke Qiang stress asymptomatic infections equally important https://www.ntdtv.com/b5/2020/03/30/a102811435.html

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 Picture, copyright by : Gan Yung Chyan, KUCINTA SETIA